Oncolytic vaccinia virus in combination with radiation shows synergistic antitumor efficacy in pancreatic cancer Journal Article


Authors: Dai, M. H.; Liu, S. L.; Chen, N. G.; Zhang, T. P.; You, L.; Q. Zhang, F.; Chou, T. C.; Szalay, A. A.; Fong, Y.; Zhao, Y. P.
Article Title: Oncolytic vaccinia virus in combination with radiation shows synergistic antitumor efficacy in pancreatic cancer
Abstract: Combining oncolytic viruses with conventional therapy such as radiation is an innovative option for pancreatic cancer. We demonstrated that combination of GLV-1h151 and radiation yielded a synergistic cytotoxic effect, with the greatest effect achieved in the AsPC-1cell line. Combination treatment significantly increased apoptosis compared with either single treatment or the control group. In mice bearing human pancreatic tumor xenografts, combination treatment resulted in significantly enhanced inhibition of tumor growth. No evidence of toxicity was observed in mice. These results indicate that the combination of GLV-1h151 and radiation has great potential for translation into clinic practice. © 2013 Elsevier Ireland Ltd.
Keywords: pancreatic cancer; virus; synergism
Journal Title: Cancer Letters
Volume: 344
Issue: 2
ISSN: 0304-3835
Publisher: Elsevier Ireland Ltd.  
Date Published: 2014-03-28
Start Page: 282
End Page: 290
Language: English
DOI: 10.1016/j.canlet.2013.11.007
PROVIDER: scopus
PUBMED: 24321381
DOI/URL:
Notes: Export Date: 3 March 2014 -- CODEN: CALED -- Source: Scopus
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  2. Ting-Chao Chou
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