Towards a unified model of RAF inhibitor resistance Journal Article

   


Authors: Solit, D. B.; Rosen, N.
Article Title: Towards a unified model of RAF inhibitor resistance
Abstract: ATP-competitive RAF inhibitors elicit profound but often temporary antitumor responses in patients with BRAF -mutant melanoma. Analysis of tumor samples collected at the time of disease progression indicates that alterations within the extracellular signal-regulated kinase (ERK) pathway that result in reactivation of ERK signaling are present in most patients. Mutations in the phosphoinositide 3-kinase/AKT pathway that enhance the adaptive response to RAF inhibitors also contribute to RAF inhibitor resistance in a subset of patients. © 2014 AACR.
Journal Title: Cancer Discovery
Volume: 4
Issue: 1
ISSN: 2159-8274
Publisher: American Association for Cancer Research  
Date Published: 2014-01-01
Start Page: 27
End Page: 30
Language: English
DOI: 10.1158/2159-8290.cd-13-0961
PROVIDER: scopus
PUBMED: 24402945
PMCID: PMC4986142
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84891895334&partnerID=40&md5=4de65867b489dce4d97fd6c12667e334
Notes: Export Date: 3 February 2014 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Neal Rosen
    425 Rosen
  2. David Solit
    779 Solit
Related MSK Work