Mining the epigenetic landscape in ALL Journal Article
| Authors: | LaFave, L. M.; Levine, R. L. |
| Article Title: | Mining the epigenetic landscape in ALL |
| Abstract: | The significance of epigenomic aberrations in cancer development has been underscored by the discovery of mutations in key chromatin modifiers, most notably in hematological malignancies. A new study of pediatric acute lymphoblastic leukemia (ALL) demonstrates the usefulness of mapping global epigenetic signatures and applying these data in a framework to identify and characterize underlying somatic genetic alterations in human cancers. |
| Keywords: | genetics; note; animal; animals; acute lymphoblastic leukemia; histone; chromatin; histone-lysine n-methyltransferase; precursor cell lymphoblastic leukemia-lymphoma; repressor protein; repressor proteins; histones; histone lysine methyltransferase; humans; human; female; whsc1 protein, human |
| Journal Title: | Nature Genetics |
| Volume: | 45 |
| Issue: | 11 |
| ISSN: | 1061-4036 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2013-11-01 |
| Start Page: | 1269 |
| End Page: | 1270 |
| Language: | English |
| PUBMED: | 24165727 |
| PROVIDER: | scopus |
| DOI: | 10.1038/ng.2808 |
| DOI/URL: | |
| Notes: | Export Date: 3 February 2014 -- Source: Scopus |
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