Surgical margins in breast conservation Journal Article


Authors: Chiappa, C.; Rovera, F.; Corben, A. D.; Fachinetti, A.; De Berardinis, V.; Marchionini, V.; Rausei, S.; Boni, L.; Dionigi, G.; Dionigi, R.
Article Title: Surgical margins in breast conservation
Abstract: Breast cancer is the most common tumor affecting women worldwide. Breast-conserving therapy (BCT) followed by irradiation nowadays is the treatment of choice for early-stage disease; there is no difference in long-term survival between mastectomy and BCT combined with external radiotherapy. A positive margin is associated with increased risk of local recurrences after BCT for invasive breast cancer and ductal carcinoma in situ. The exact definition of an adequate surgical margin after breast cancer resection has long been debated among physicians and represents an area of considerable variation in clinical practice. There is a lack of standardization in the pathology methods of margin evaluation, which yields little consensus regarding what constitutes an adequate negative margin. As a consequence, patient management varies widely based on the threshold that surgeons accept for adequate margins and the subsequent need for re-excision. We analyze and discuss recent literature about this topic both from the pathological and from the surgical point of view. © 2013 Elsevier Ltd and Surgical Associates Ltd.
Keywords: cancer survival; surgical technique; review; cancer recurrence; cancer risk; cancer adjuvant therapy; cancer radiotherapy; clinical practice; consensus; breast cancer; mastectomy; tumor volume; standardization; adjuvant chemotherapy; breast carcinoma; carcinoma in situ; partial mastectomy; measurement; breast surgery; intraductal carcinoma; lobular carcinoma in situ; optical coherence tomography; surgical margin; surgical margins; tumor invasion; ink; long term survival; priority journal; breast conservative therapy; radial margin; shaved margin; shaving the walls of the lumpectomy cavity
Journal Title: International Journal of Surgery
Volume: 11
Issue: S1
ISSN: 1743-9191
Publisher: Elsevier Science, Inc.  
Date Published: 2013-12-01
Start Page: S69
End Page: S72
Language: English
DOI: 10.1016/s1743-9191(13)60021-7
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 3 February 2014 -- Source: Scopus
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MSK Authors
  1. Adriana Dionigi Corben
    56 Corben