Accuracy of the extent of bladder cancer nodal metastases found at pelvic lymphadenectomy at the time of cystectomy: Relation to primary tumor stage Journal Article
| Authors: | Rabbani, F.; Lee, C.; Chang, S. S.; Lerner, S. P.; Wood, D. P.; Herr, H. W. |
| Article Title: | Accuracy of the extent of bladder cancer nodal metastases found at pelvic lymphadenectomy at the time of cystectomy: Relation to primary tumor stage |
| Abstract: | Objectives: To determine the minimum number of nodes (nmin) that need to be removed to ascertain N0 status with 90/95% certainty, and to determine the maximum number of nodes theoretically involved for a given number 'm' of involved nodes reported out of a total of 'n' nodes examined. Methods: 2,025 patients underwent cystectomy and pelvic lymphadenectomy, with pathologic stage ≤pT2 in 1,132 (55.9%) and ≥pT3 in 893 (44.1%). A mathematical model was utilized, using incidences derived from those having ≥10 nodes retrieved. Results: For stage ≤pT2 and 0, 1, or 2 positive nodes reported, nmin are 2, 27, and 28, respectively, for 90% accuracy and 12, 29, and 29, respectively, for 95% accuracy. For stage ≥pT3 and 0, 1, or 2 positive nodes reported, nmin are 19, 28, and 29, respectively, for 90% accuracy and 24, 29, and 30, respectively, for 95% accuracy. Conclusions: Accuracy of the extent of nodal involvement depends on the number of positive nodes reported, total number of nodes retrieved, and pathologic stage. This model allows clinicians to assess potential underestimation of the 'true' number of involved nodes for a given number of positive nodes out of a total number reported. © 2010 S. Karger AG, Basel. |
| Keywords: | controlled study; primary tumor; major clinical study; cancer staging; lymph node metastasis; lymph nodes; lymph node excision; accuracy; pelvis lymphadenectomy; incidence; bladder cancer; mathematical model; lymph node; cystectomy; physician; bladder neoplasms |
| Journal Title: | Urologia Internationalis |
| Volume: | 84 |
| Issue: | 1 |
| ISSN: | 0042-1138 |
| Publisher: | S. Karger AG |
| Date Published: | 2010-02-01 |
| Start Page: | 14 |
| End Page: | 22 |
| Language: | English |
| DOI: | 10.1159/000273460 |
| PROVIDER: | scopus |
| PUBMED: | 20173363 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: URINA" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work