Molecular pathogenesis of AML: Translating insights to the clinic Journal Article
| Author: | Levine, R. L. |
| Article Title: | Molecular pathogenesis of AML: Translating insights to the clinic |
| Abstract: | Specific combinations of mutations, including FLT3 and IDH1/IDH2/TET2, frequently co-occur in acute myeloid leukemia (AML) and are associated with poor prognosis. These mutation combinations can be modeled in mice to provide a more genetically accurate model of AML. Within these models, stem cells may be different depending on how experiments are conducted and based on context. No one mutation can turn on a gene; rather the perfect storm of the right genes in the right cell is necessary to produce AML. Furthermore, this understanding is therapeutically relevant. Rapid and accurate targeted DNA sequencing will identify mutations of prognostic and therapeutic significance and will guide treatment choices in the future. © 2013 Elsevier Ltd. All rights reserved. |
| Keywords: | acute granulocytic leukemia; gene mutation; gene sequence; overall survival; pathogenesis; nonhuman; allele; gene; gene expression profiling; cytogenetics; stem cell; dna sequence; tet2 gene; leukemia remission; aml; asxl1 gene; tet2; idh1 gene; idh2 gene; acute myeloid leukemia; flt3; gemtuzumab; cancer prognosis; dnmt3a gene; flt3 gene; dna sequencing; human; priority journal; article; murine models |
| Journal Title: | Best Practice and Research: Clinical Haematology |
| Volume: | 26 |
| Issue: | 3 |
| ISSN: | 1521-6926 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2013-09-01 |
| Start Page: | 245 |
| End Page: | 248 |
| Language: | English |
| DOI: | 10.1016/j.beha.2013.10.003 |
| PROVIDER: | scopus |
| PMCID: | PMC3869618 |
| PUBMED: | 24309525 |
| DOI/URL: | |
| Notes: | Export Date: 2 January 2014 -- CODEN: BPRCA -- Source: Scopus |
