Deformity stabilization and improvement in men with untreated Peyronie's disease Journal Article
| Authors: | Berookhim, B. M.; Choi, J.; Alex, B.; Mulhall, J. P. |
| Article Title: | Deformity stabilization and improvement in men with untreated Peyronie's disease |
| Abstract: | Objective To define predictors of the deformity stabilisation and improvement in men with untreated Peyronie's disease (PD). Patients and Methods The study population consisted of patients with PD-associated uniplanar curvature, who opted for no treatment and were followed for at least 12 months. All patients had deformity assessment (DA) performed on initial presentation and at follow-up. Stabilisation of PD was defined as no change between DAs (±10°), while improvement and progression were defined as ≥10° change. Patients were subdivided into different groups based on time to presentation: ≤6 months (A), 7-12 months (B), and 13-18 months (C). Multivariable analysis was used to define predictors of stabilisation and improvement. Results In all, 176 men met the inclusion criteria. The mean age was 54 years, with a mean (sd) PD duration of 9 (12) months and mean curvature of 42 (27)°. In all, 67% of the entire population had no change in deformity over time, 12% improved with a mean (sd) change of 27 (14)°, and 21% worsened with a mean (sd) change of 22 (11)°. On multivariate analysis, predictors of stabilisation included: time to presentation of >6 months (odds ratio [OR] 2.4, P < 0.01), per decade increase in age (OR 1.5, P < 0.05), and age (r = 0.32, P < 0.05). Predictors of improvement included: time to presentation of ≤6 months (OR 4.1, P < 0.001), and per decade decrease in age (OR 2.1, P < 0.01). Conclusions In men with uniplanar curvature, PD stabilisation and improvement rates change with time-to-presentation and patient age. These data may aid in counselling patients with PD. © 2013 The Authors. BJU International © 2013 BJU International. |
| Keywords: | penis; peyronie's disease; penile induration; natural history |
| Journal Title: | BJU International |
| Volume: | 113 |
| Issue: | 1 |
| ISSN: | 1464-4096 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2014-01-01 |
| Start Page: | 133 |
| End Page: | 136 |
| Language: | English |
| DOI: | 10.1111/bju.12346 |
| PROVIDER: | scopus |
| PUBMED: | 24053665 |
| DOI/URL: | |
| Notes: | Export Date: 2 January 2014 -- CODEN: BJINF -- Source: Scopus |
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