Split T-cell tolerance as a guide for the development of tumor antigen-specific immunotherapy Journal Article

   


Authors: Tsuji, T.; Gnjatic, S.
Article Title: Split T-cell tolerance as a guide for the development of tumor antigen-specific immunotherapy
Abstract: Tumor antigens NY-ESO-1 and p53 both frequently induce spontaneous serum antibody in cancer patients. While NYESO-1-specific CD8+ and CD4+ circulating T-cells occur mainly in NY-ESO-1-seropositive patients, p53-specific circulating CD8+ and CD4+ T-cells are respectively undetectable and common in most individuals. Understanding T-cell split tolerance can help define suitable targets for immunotherapy. © 2012 Landes Bioscience.
Keywords: protein expression; unclassified drug; cd8+ t lymphocyte; t lymphocyte; cytotoxic t lymphocyte antigen 4 antibody; cancer immunotherapy; drug effect; protein p53; tumor antigen; immunological tolerance; cellular immunity; cancer vaccine; antigen specificity; ny eso 1 antigen; immunogenicity; antibody response; cd4+ t lymphocyte; tumor immunity; immunomodulation; adaptive immunity; p53; tolerance; glucocorticoid induced tumor necrosis factor receptor antibody; memory t lymphocyte; ny-eso-1; serum antibody; programmed death 1 receptor antibody; receptor antibody; cd8 t lymphocytes
Journal Title: OncoImmunology
Volume: 1
Issue: 3
ISSN: 2162-4011
Publisher: Landes Bioscience  
Date Published: 2012-05-01
Start Page: 405
End Page: 407
Language: English
DOI: 10.4161/onci.19310
PROVIDER: scopus
PMCID: PMC3382850
PUBMED: 22737632
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84886944471&partnerID=40&md5=97524be202604d3ad3398a5487be57ab
Notes: --- - "Export Date: 2 December 2013" - "Source: Scopus"
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Sacha Gnjatic
    113 Gnjatic
  2. Takemasa Tsuji
    14 Tsuji
Related MSK Work