Microenvironmental regulation of tumor progression and metastasis Journal Article


Authors: Quail, D. F.; Joyce, J. A.
Article Title: Microenvironmental regulation of tumor progression and metastasis
Abstract: Cancers develop in complex tissue environments, which they depend on for sustained growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor microenvironment (TME) are genetically stable and thus represent an attractive therapeutic target with reduced risk of resistance and tumor recurrence. However, specifically disrupting the pro-tumorigenic TME is a challenging undertaking, as the TME has diverse capacities to induce both beneficial and adverse consequences for tumorigenesis. Furthermore, many studies have shown that the microenvironment is capable of normalizing tumor cells, suggesting that re-education of stromal cells, rather than targeted ablation per se, may be an effective strategy for treating cancer. Here we discuss the paradoxical roles of the TME during specific stages of cancer progression and metastasis, as well as recent therapeutic attempts to re-educate stromal cells within the TME to have anti-tumorigenic effects. © 2013 Nature America, Inc.
Journal Title: Nature Medicine
Volume: 19
Issue: 11
ISSN: 1078-8956
Publisher: Nature Publishing Group  
Date Published: 2013-11-01
Start Page: 1423
End Page: 1437
Language: English
DOI: 10.1038/nm.3394
PROVIDER: scopus
PUBMED: 24202395
PMCID: PMC3954707
DOI/URL:
Notes: --- - Cited By (since 1996):1 - "Export Date: 2 December 2013" - "CODEN: NAMEF" - "Source: Scopus"
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  1. Johanna A Joyce
    67 Joyce
  2. Daniela Francis Quail
    13 Quail