Comparison of automated platelet counts and potential effect on transfusion decisions in cancer patients Journal Article
| Authors: | Marionneaux, S.; Francisco, N.; Chan, V.; Hanenberg, J.; Rafael, J.; Chua, C.; Jia, R.; Yao, J.; Lynch, J.; Maslak, P. |
| Article Title: | Comparison of automated platelet counts and potential effect on transfusion decisions in cancer patients |
| Abstract: | Objectives: To evaluate the accuracy of platelet counts from various hematology analyzers using a reference immunologic method. Methods: We tested 403 samples with platelet counts less than 50 × 109/L with the Advia (Siemens, Tarrytown, NY), Sysmex (Mundelein, IL), and Abbott (Santa Clara, CA) analyzers. Results: All methods showed a positive bias, especially at less than 20 × 109/L and less than 10 × 109/L. Undertransfusion risk ranged from 9.1% to 43.3 % in the groups below 20 × 109/L and below 10 × 109/L, respectively. For patients with optical counts more than 10 × 109/L and CD61 less than 10 × 109/L , 64.5% were transfused within 24 hours of the reported count, while 35.5% were transfused in more than 24 hours, after a subsequent optical platelet count of 10 × 109/L or less was reported. Conclusions: Although optical and impedance methods were shown to be falsely increased in severely thrombocytopenic samples, further studies are needed to determine if more accurate methods would be clinically useful. © American Society for Clinical Pathology. |
| Keywords: | clinical article; controlled study; human cell; microscopy; cancer patient; diagnostic accuracy; sensitivity and specificity; thrombocytopenia; automation; disease severity; hematologic malignancy; thrombocyte count; clinical decision making; immune function test; predictive value; thrombocyte transfusion; platelet count; impedance; hematology/oncology; beta3 integrin; platelet transfusion; autoanalyzer; hematology analyzer; transfusion safety |
| Journal Title: | American Journal of Clinical Pathology |
| Volume: | 140 |
| Issue: | 5 |
| ISSN: | 0002-9173 |
| Publisher: | Oxford University Press |
| Date Published: | 2013-11-01 |
| Start Page: | 747 |
| End Page: | 754 |
| Language: | English |
| DOI: | 10.1309/ajcp58intitvgqzi |
| PROVIDER: | scopus |
| PUBMED: | 24124156 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 December 2013" - "CODEN: AJCPA" - "Source: Scopus" |
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