Focal treatment or observation of prostate cancer: Pretreatment accuracy of transrectal ultrasound biopsy and T(2)-weighted MRI Journal Article
| Authors: | Nogueira, L.; Wang, L.; Fine, S. W.; Pinochet, R; Kurta, J. M.; Katz, D.; Savage, C. J.; Cronin, A. M.; Hricak, H.; Scardino, P. T.; Akin, O.; Coleman, J. A. |
| Article Title: | Focal treatment or observation of prostate cancer: Pretreatment accuracy of transrectal ultrasound biopsy and T(2)-weighted MRI |
| Abstract: | Objectives: To test the hypothesis that men with prostate cancer (PCA) and preoperative disease features considered favorable for focal treatment would be accurately characterized with transrectal biopsy and prostate magnetic resonance imaging (MRI) by performing a retrospective analysis of a selected cohort of such patients treated with radical prostatectomy (RP). Methods: A total of 202 patients with PCA who had preoperative MRI and low-risk biopsy criteria (no Gleason grade 4/5, 1 involved core, <2 mm, PSA density ≤0.10, clinical stage ≤T2a) were included in the study. Indolent RP pathology was defined as no Gleason 4/5, organ confined, tumor volume <0.5 mL, and negative surgical margins. MRI ability to locate and determine the tumor extent was assessed. Results: After RP, 101 men (50%) had nonindolent cancer. Multifocal and bilateral tumors were present in 81% and 68% of patients, respectively. MRI indicated extensive disease in 16 (8%). MRI sensitivity to locate PCA ranged from 2% to 20%, and specificity from 91% to 95%. On univariate analysis, MRI evidence of extracapsular extension (P = .027) and extensive disease (P = .001) were associated with nonindolent cancer. On multivariate analysis, only the latter remained as significant predictor (P = .0018). Conclusions: Transrectal biopsy identified men with indolent tumors favorable for focal treatment in 50% of cases. MRI findings of extracapsular extension and extensive tumor involving more than half of the gland are associated with unfavorable features, and may be useful in excluding patients from focal treatment. According to these data, endorectal MRI is not sufficient to localize small tumors for focal treatment. © 2010 Elsevier Inc. All rights reserved. |
| Keywords: | adult; controlled study; middle aged; retrospective studies; major clinical study; cancer risk; cancer staging; nuclear magnetic resonance imaging; magnetic resonance imaging; preoperative evaluation; accuracy; reproducibility of results; biopsy; prostate cancer; gleason score; prostatic neoplasms; prostatectomy; prostate biopsy; transrectal ultrasonography; diffusion weighted imaging; ultrasonography; rectum; rectum biopsy |
| Journal Title: | Urology |
| Volume: | 75 |
| Issue: | 2 |
| ISSN: | 0090-4295 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2010-02-01 |
| Start Page: | 472 |
| End Page: | 477 |
| Language: | English |
| DOI: | 10.1016/j.urology.2009.04.061 |
| PUBMED: | 19643467 |
| PROVIDER: | scopus |
| PMCID: | PMC3651887 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 20 April 2011" - "CODEN: URGYA" - "Source: Scopus" |
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