Stereotactic body radiation therapy for primary lung cancers >3 centimeters Journal Article
| Authors: | Cuaron, J. J.; Yorke, E. D.; Foster, A.; Hsu, M.; Zhang, Z.; Liu, F.; Jackson, A.; Mychalczak, B.; Rosenzweig, K. E.; Wu, A. J.; Rimner, A. |
| Article Title: | Stereotactic body radiation therapy for primary lung cancers >3 centimeters |
| Abstract: | INTRODUCTION:: A retrospective analysis of the outcomes of stereotactic body radiation therapy (SBRT) in the treatment of large (>3 cm) non-small-cell lung cancers (NSCLCs). METHODS:: Between February 2007 and November 2011, 63 patients with T2-T4N0 NSCLC were treated with SBRT. Toxicity was graded per Common Terminology Criteria for Adverse Events, version 4.0. Local failure-free survival (LFFS), recurrence-free survival, and overall survival curves were estimated using the Kaplan-Meier method and univariate analysis was performed using Cox regression. RESULTS:: Median follow-up was 16.9 months. One- and 2-year LFFS was 88.8% and 75.7%, 1- and 2-year recurrence-free survival was 59.0% and 41.6%, and 1- and 2-year overall survival was 77.1% and 57.6%, respectively. Planning target volume less than 106 cm was associated with a significantly higher 1- and 2-year LFFS (p =0.05). Grade 2 or higher acute and late pulmonary toxicities occurred in 19.3% and 19.3% of patients, respectively, and were not associated with common dose-volume parameters; 22.8% of patients developed grade 2 or higher chest wall pain, which was significantly associated with chest wall V30 70 cm or more (p = 0.03). CONCLUSIONS:: SBRT for larger NSCLC tumors achieves high LFFS with acceptable toxicity. LFFS was worse with planning target volume 106 cm or more. Grade 2 or higher chest wall pain was associated with chest wall V30 70 cm or more. Copyright © 2013 by the International Association for the Study of Lung. |
| Keywords: | adult; human tissue; aged; primary tumor; major clinical study; overall survival; radiation dose; cancer staging; outcome assessment; follow up; lung toxicity; lung non small cell cancer; lung cancer; thorax pain; cancer size; toxicity; stereotactic body radiation therapy; recurrence free survival; large tumors; local failure free survival |
| Journal Title: | Journal of Thoracic Oncology |
| Volume: | 8 |
| Issue: | 11 |
| ISSN: | 1556-0864 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2013-11-01 |
| Start Page: | 1396 |
| End Page: | 1401 |
| Language: | English |
| DOI: | 10.1097/JTO.0b013e3182a47181 |
| PROVIDER: | scopus |
| PUBMED: | 24077457 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 December 2013" - "Source: Scopus" |
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