Local approaches to hereditary breast cancer Journal Article
| Authors: | Cooper, B. T.; Murphy, J. O.; Sacchini, V.; Formenti, S. C. |
| Article Title: | Local approaches to hereditary breast cancer |
| Abstract: | The diagnostic and local treatment modalities of hereditary breast cancer (HBC) are evolving based on emerging evidence from new imaging, radiotherapy and surgical studies. The optimal selection of diagnostic and therapeutic strategies for the individual HBC patient remains an area of active research in this relatively new patient population. In this context, some rational pathways of intervention are currently available to both reduce cancer risk in mutation carriers without a cancer diagnosis, as well as to reduce the risk of recurrence or new cancers among the carriers already diagnosed with a malignancy. It is encouraging to notice to what degree certain interventions have successfully reduced both the risk of malignancy and the anxiety associated with this genetic diagnosis. This updated report aims at summarizing the most recent findings, while it identifies the areas of uncertainty that remain, and continue to present difficult challenges, particularly among younger HBC patients.© The Author 2013. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. |
| Keywords: | radiation; brca1; brca2; hereditary breast cancer; radiation-induced malignancy |
| Journal Title: | Annals of Oncology |
| Volume: | 24 |
| Issue: | Suppl. B |
| ISSN: | 0923-7534 |
| Publisher: | Oxford University Press |
| Date Published: | 2013-11-01 |
| Start Page: | viii54 |
| End Page: | viii60 |
| Language: | English |
| DOI: | 10.1093/annonc/mdt327 |
| PROVIDER: | scopus |
| PUBMED: | 24131971 |
| DOI/URL: | |
| Notes: | --- - Cited By (since 1996):1 - "Export Date: 2 December 2013" - "Art. No.: mdt327" - "CODEN: ANONE" - "Source: Scopus" |
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