Radiation dose-volume effects in radiation-induced rectal injury Journal Article
| Authors: | Michalski, J. M.; Gay, H.; Jackson, A.; Tucker, S. L.; Deasy, J. O. |
| Article Title: | Radiation dose-volume effects in radiation-induced rectal injury |
| Abstract: | The available dose/volume/outcome data for rectal injury were reviewed. The volume of rectum receiving ≥60Gy is consistently associated with the risk of Grade ≥2 rectal toxicity or rectal bleeding. Parameters for the Lyman-Kutcher-Burman normal tissue complication probability model from four clinical series are remarkably consistent, suggesting that high doses are predominant in determining the risk of toxicity. The best overall estimates (95% confidence interval) of the Lyman-Kutcher-Burman model parameters are n = 0.09 (0.04-0.14); m = 0.13 (0.10-0.17); and TD50 = 76.9 (73.7-80.1) Gy. Most of the models of late radiation toxicity come from three-dimensional conformal radiotherapy dose-escalation studies of early-stage prostate cancer. It is possible that intensity-modulated radiotherapy or proton beam dose distributions require modification of these models because of the inherent differences in low and intermediate dose distributions. © 2010 Elsevier Inc. All rights reserved. |
| Keywords: | three dimensional; intensity modulated radiation therapy; gastrointestinal hemorrhage; cancer radiotherapy; radiation dose; biological model; models, biological; radiotherapy dosage; radiotherapy; radiation injury; risk factor; radiation response; risk; mathematical model; prostate cancer; confidence interval; disease severity; intensity-modulated radiotherapy; models, statistical; diabetes mellitus; radiation injuries; forecasting; enteritis; radiation hazard; radiotherapy, conformal; abdominal surgery; toxicity; androgen deprivation therapy; organ size; radiation dose distribution; biological radiation effects; prostate cancers; proton radiation; hemorrhoid; rectum; rectum hemorrhage; radiation toxicity; rectal toxicity; dose distributions; high dose; ntcp; normal-tissue complication probability models; rectum injury; radiation-induced; dose-escalation study; model parameters; three-dimensional conformal radiotherapy; proton therapy |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 76 |
| Issue: | 3 Suppl. |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-03-01 |
| Start Page: | S123 |
| End Page: | S129 |
| Language: | English |
| DOI: | 10.1016/j.ijrobp.2009.03.078 |
| PUBMED: | 20171506 |
| PROVIDER: | scopus |
| PMCID: | PMC3319467 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 11" - "Export Date: 20 April 2011" - "CODEN: IOBPD" - "Source: Scopus" |
