Neoadjuvant therapy of locally advanced gastric cancer Journal Article
| Authors: | Mezhir, J. J.; Tang, L. H.; Coit, D. G. |
| Article Title: | Neoadjuvant therapy of locally advanced gastric cancer |
| Abstract: | Treatment of gastric cancer has evolved with the advent of randomized trials demonstrating chemotherapeutic agents with efficacy in advanced disease. Level I evidence supports delivering chemotherapy in the neoadjuvant setting; the data shows improvement in progression-free and overall survival. A clinical response to therapy is associated with improved R0 resection rates, pathologic response, and outcome in patients with locally advanced disease. Early assessment of metabolic response to therapy can potentially be utilized to tailor treatment. © 2010 Wiley-Liss, Inc. |
| Keywords: | cancer chemotherapy; treatment outcome; treatment response; cancer surgery; overall survival; clinical trial; review; cisplatin; doxorubicin; fluorouracil; advanced cancer; patient selection; antineoplastic agents; adjuvant therapy; cancer adjuvant therapy; neoadjuvant therapy; radiotherapy, adjuvant; chemotherapy; methotrexate; biological marker; cytology; progression free survival; multiple cycle treatment; etoposide; continuous infusion; algorithms; vinblastine; risk assessment; irinotecan; patient care; folinic acid; gastrectomy; stomach cancer; epirubicin; medical literature; mitomycin; floxuridine; stomach neoplasms; decision trees; fluorodeoxyglucose; gastric cancer; perforation |
| Journal Title: | Journal of Surgical Oncology |
| Volume: | 101 |
| Issue: | 4 |
| ISSN: | 0022-4790 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2010-03-15 |
| Start Page: | 305 |
| End Page: | 314 |
| Language: | English |
| DOI: | 10.1002/jso.21483 |
| PUBMED: | 20187070 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 20 April 2011" - "CODEN: JSONA" - "Source: Scopus" |
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