Lipid-modified aminoglycoside derivatives for in vivo siRNA delivery Journal Article
| Authors: | Zhang, Y.; Pelet, J. M.; Heller, D. A.; Dong, Y.; Chen, D.; Gu, Z.; Joseph, B. J.; Wallas, J.; Anderson, D. G. |
| Article Title: | Lipid-modified aminoglycoside derivatives for in vivo siRNA delivery |
| Abstract: | Rationally designed siRNA delivery materials that are enabled by lipid-modified aminoglycosides are demonstrated. Leading materials identified are able to self-assemble with siRNA into well-defined nanoparticles and induce efficient gene knockdown both in vitro and in vivo. Histology studies and liver function tests reveal that no apparent toxicity is caused by these nanoparticles at doses over two orders of magnitude. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| Keywords: | genes; rna; nanoparticles; nanoparticle; drug delivery; sirna; aminoglycoside; aminoglycosides; sirna delivery; gene knock down; gene knockdown; liver functions; orders of magnitude; self-assemble; well-defined nanoparticles |
| Journal Title: | Advanced Materials |
| Volume: | 25 |
| Issue: | 33 |
| ISSN: | 0935-9648 |
| Publisher: | Wiley V C H Verlag Gmbh |
| Date Published: | 2013-09-06 |
| Start Page: | 4641 |
| End Page: | 4645 |
| Language: | English |
| DOI: | 10.1002/adma.201301917 |
| PROVIDER: | scopus |
| PUBMED: | 23813808 |
| PMCID: | PMC3898629 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 October 2013" - "CODEN: ADVME" - "Source: Scopus" |
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