Lipid-modified aminoglycoside derivatives for in vivo siRNA delivery Journal Article


Authors: Zhang, Y.; Pelet, J. M.; Heller, D. A.; Dong, Y.; Chen, D.; Gu, Z.; Joseph, B. J.; Wallas, J.; Anderson, D. G.
Article Title: Lipid-modified aminoglycoside derivatives for in vivo siRNA delivery
Abstract: Rationally designed siRNA delivery materials that are enabled by lipid-modified aminoglycosides are demonstrated. Leading materials identified are able to self-assemble with siRNA into well-defined nanoparticles and induce efficient gene knockdown both in vitro and in vivo. Histology studies and liver function tests reveal that no apparent toxicity is caused by these nanoparticles at doses over two orders of magnitude. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Keywords: genes; rna; nanoparticles; nanoparticle; drug delivery; sirna; aminoglycoside; aminoglycosides; sirna delivery; gene knock down; gene knockdown; liver functions; orders of magnitude; self-assemble; well-defined nanoparticles
Journal Title: Advanced Materials
Volume: 25
Issue: 33
ISSN: 0935-9648
Publisher: Wiley V C H Verlag Gmbh  
Date Published: 2013-09-06
Start Page: 4641
End Page: 4645
Language: English
DOI: 10.1002/adma.201301917
PROVIDER: scopus
PUBMED: 23813808
PMCID: PMC3898629
DOI/URL:
Notes: --- - "Export Date: 1 October 2013" - "CODEN: ADVME" - "Source: Scopus"
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  1. Daniel Alan Heller
    112 Heller
  2. Jasmine M Wallas
    2 Wallas
  3. Brian Jude Joseph
    9 Joseph