Authors: | Tyler, E. M.; Koehne, G. |
Article Title: | The emergence of WT1-specific t-cell responses following allogeneic T cell-depleted hematopoietic stem cell transplantation and low-dose donor lymphocyte infusions is associated with a graft- vs. -myeloma effect |
Abstract: | The development of T-cell responses specific for myeloma-associated antigens correlates with improved clinical outcomes in multiple myeloma patients undergoing allogeneic T cell-depleted hematopoietic stem cell transplantation and donor lymphocyte infusions. Thus, immunotherapeutic strategies that further increase the frequency of Wilms tumor 1 (WT 1)- specific T cells may provide clinical benefits to multiple myeloma patients. © 2013 Landes Bioscience. |
Keywords: | allogeneic stem cell transplantation; multiple myeloma; donor lymphocyte infusion; graft- vs. -myeloma effect; wt1-specific cytotoxic t cells |
Journal Title: | OncoImmunology |
Volume: | 2 |
Issue: | 7 |
ISSN: | 2162-4011 |
Publisher: | Landes Bioscience |
Date Published: | 2013-07-01 |
Start Page: | e24963 |
Language: | English |
DOI: | 10.4161/onci.24963 |
PROVIDER: | scopus |
PMCID: | PMC3782135 |
PUBMED: | 24073375 |
DOI/URL: | |
Notes: | --- - "Export Date: 1 October 2013" - "Source: Scopus" |