The emergence of WT1-specific t-cell responses following allogeneic T cell-depleted hematopoietic stem cell transplantation and low-dose donor lymphocyte infusions is associated with a graft- vs. -myeloma effect Journal Article


Authors: Tyler, E. M.; Koehne, G.
Article Title: The emergence of WT1-specific t-cell responses following allogeneic T cell-depleted hematopoietic stem cell transplantation and low-dose donor lymphocyte infusions is associated with a graft- vs. -myeloma effect
Abstract: The development of T-cell responses specific for myeloma-associated antigens correlates with improved clinical outcomes in multiple myeloma patients undergoing allogeneic T cell-depleted hematopoietic stem cell transplantation and donor lymphocyte infusions. Thus, immunotherapeutic strategies that further increase the frequency of Wilms tumor 1 (WT 1)- specific T cells may provide clinical benefits to multiple myeloma patients. © 2013 Landes Bioscience.
Keywords: allogeneic stem cell transplantation; multiple myeloma; donor lymphocyte infusion; graft- vs. -myeloma effect; wt1-specific cytotoxic t cells
Journal Title: OncoImmunology
Volume: 2
Issue: 7
ISSN: 2162-4011
Publisher: Landes Bioscience  
Date Published: 2013-07-01
Start Page: e24963
Language: English
DOI: 10.4161/onci.24963
PROVIDER: scopus
PMCID: PMC3782135
PUBMED: 24073375
DOI/URL:
Notes: --- - "Export Date: 1 October 2013" - "Source: Scopus"
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  1. Guenther Koehne
    192 Koehne
  2. Eleanor M Tyler
    9 Tyler