Prostate-specific kallikrein-related peptidases and their relation to prostate cancer biology and detection: Established relevance and emerging roles Journal Article

   

Authors:	Thorek, D. L. J.; Evans, M. J.; Carlsson, S. V.; Ulmert, D.; Lilja, H.
Article Title:	Prostate-specific kallikrein-related peptidases and their relation to prostate cancer biology and detection: Established relevance and emerging roles
Abstract:	Kallikreins are a family of serine proteases with a range of tissue-specific and essential proteolytic functions. Among the best studied are the prostate tissue-specific KLK2 and KLK3 genes and their secreted protease products, human kallikrein 2, hk2, and prostate-specific antigen (PSA). Members of the so-called classic kallikreins, these highly active trypsin-like serine proteases play established roles in human reproduction. Both hK2 and PSA expression is regulated by the androgen receptor which has a fundamental role in prostate tissue development and progression of disease. This feature, combined with the ability to sensitively detect different forms of these proteins in blood and biopsies, result in a crucially important biomarker for the presence and recurrence of cancer. Emerging evidence has begun to suggest a role for these kallikreins in critical vascular events. This review discusses the established and developing biological roles of hK2 and PSA, as well as the historical and advanced use of their detection to accurately and non-invasively detect and guide treatment of prostatic disease. © Schattauer 2013.
Keywords:	somatomedin; protein expression; unclassified drug; disease course; review; doxorubicin; cancer growth; nonhuman; cell proliferation; prostate specific antigen; gene; inflammation; immunofluorescence; enzyme linked immunosorbent assay; cancer mortality; prostate cancer; serine proteinase; kallikrein; cell migration; androgen receptor; blood pressure; homeostasis; androgen deprivation therapy; alpha 2 macroglobulin; klk3 gene; kallikrein 2; klk2 gene; kallikrein inhibitor
Journal Title:	Thrombosis and Haemostasis
Volume:	110
Issue:	3
ISSN:	0340-6245
Publisher:	Schattauer Publishers, Stuttgart
Date Published:	2013-08-28
Start Page:	484
End Page:	492
Language:	English
DOI:	10.1160/th13-04-0275
PROVIDER:	scopus
PUBMED:	23903407
PMCID:	PMC4029064
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84883254543&partnerID=40&md5=13a14c42722a06a74f5a7df66449fd00
Notes:	--- - Cited By (since 1996):1 - "Export Date: 1 October 2013" - "CODEN: THHAD" - "Source: Scopus"

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