The average enzyme principle Journal Article
| Authors: | Reznik, E.; Chaudhary, O.; Segrè, D. |
| Article Title: | The average enzyme principle |
| Abstract: | The Michaelis-Menten equation for an irreversible enzymatic reaction depends linearly on the enzyme concentration. Even if the enzyme concentration changes in time, this linearity implies that the amount of substrate depleted during a given time interval depends only on the average enzyme concentration. Here, we use a time re-scaling approach to generalize this result to a broad category of multi-reaction systems, whose constituent enzymes have the same dependence on time, e.g. they belong to the same regulon. This "average enzyme principle" provides a natural methodology for jointly studying metabolism and its regulation. © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
| Keywords: | controlled study; enzymology; algorithms; enzyme regulation; kinetics; enzyme analysis; catalysis; enzyme kinetics; enzyme substrate complex; models, chemical; enzymes; enzyme mechanism; enzyme synthesis; systems biology; enzyme metabolism; metabolic networks and pathways; michaelis menten kinetics; michaelis-menten; regulon; metabolic network; enzymatic degradation; average enzyme principle |
| Journal Title: | FEBS Letters |
| Volume: | 587 |
| Issue: | 17 |
| ISSN: | 0014-5793 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2013-09-02 |
| Start Page: | 2891 |
| End Page: | 2894 |
| Language: | English |
| DOI: | 10.1016/j.febslet.2013.07.032 |
| PROVIDER: | scopus |
| PUBMED: | 23892076 |
| PMCID: | PMC3983706 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 October 2013" - "CODEN: FEBLA" - "Source: Scopus" |
