Radiation associated brainstem injury Journal Article
| Authors: | Mayo, C.; Yorke, E.; Merchant, T. E. |
| Article Title: | Radiation associated brainstem injury |
| Abstract: | Publications relating brainstem radiation toxicity to quantitative dose and dose-volume measures derived from three-dimensional treatment planning were reviewed. Despite the clinical importance of brainstem toxicity, most studies reporting brainstem effects after irradiation have fewer than 100 patients. There is limited evidence relating toxicity to small volumes receiving doses above 60-64 Gy using conventional fractionation and no definitive criteria regarding more subtle dose-volume effects or effects after hypofractionated treatment. On the basis of the available data, the entire brainstem may be treated to 54 Gy using conventional fractionation using photons with limited risk of severe or permanent neurological effects. Smaller volumes of the brainstem (1-10 mL) may be irradiated to maximum doses of 59 Gy for dose fractions ≤2 Gy; however, the risk appears to increase markedly at doses >64 Gy. © 2010 Elsevier Inc. All rights reserved. |
| Keywords: | adult; child; treatment planning; radiation dose; neurotoxicity; glioma; biological model; radiation; age factors; radiation injury; childhood cancer; dose-response relationship, radiation; mathematical model; neuroblastoma; dosimetry; radiation dose fractionation; irradiation; radiation injuries; protons; meningioma; radiation hazard; radiotherapy planning, computer-assisted; maximum tolerated dose; photons; toxicity; dose fractionation; brain stem tumor; organ size; chondrosarcoma; photon; brain stem; chordoma; tolerance; radiation tolerance; radiation toxicity; dose fraction; ntcp; dose-volume; brainstem; conventional fractionations; dose-volume effects; limited risk; radiation tolerances; recombinant beta interferon; brain stem injury; cranial nerve injury |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 76 |
| Issue: | 3 Suppl. |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-03-01 |
| Start Page: | S36 |
| End Page: | S41 |
| Language: | English |
| DOI: | 10.1016/j.ijrobp.2009.08.078 |
| PUBMED: | 20171516 |
| PROVIDER: | scopus |
| PMCID: | PMC2899702 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 20 April 2011" - "CODEN: IOBPD" - "Source: Scopus" |
