Clinical activity of sunitinib in patients with advanced desmoplastic round cell tumor: A case series Journal Article
| Authors: | Italiano, A.; Kind, M.; Cioffi, A.; Maki, R. G.; Bui, B. |
| Article Title: | Clinical activity of sunitinib in patients with advanced desmoplastic round cell tumor: A case series |
| Abstract: | Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive malignancy with poor outcome occurring in adolescents and young adults. Therapeutic options for patients with advanced disease are limited. Preclinical studies have shown that VEGFR-2 and VEGFA are overexpressed in DSRCT and that DSRCT xenografts were highly responsive to anti-VEGF agents such as bevacizumab. We report here the clinical activity of sunitinib in eight patients with DSCRT. Our data suggest that sunitinib may be associated with clinical benefit even in heavily pretreated patients. © 2013 Springer-Verlag France. |
| Keywords: | adolescent; adult; clinical article; sunitinib; drug efficacy; treatment; progression free survival; medical record review; drug response; desmoplastic small round cell tumor; desmoplastic round cell tumor |
| Journal Title: | Targeted Oncology |
| Volume: | 8 |
| Issue: | 3 |
| ISSN: | 1776-2596 |
| Publisher: | Springer |
| Date Published: | 2013-09-01 |
| Start Page: | 211 |
| End Page: | 213 |
| Language: | English |
| DOI: | 10.1007/s11523-012-0251-8 |
| PROVIDER: | scopus |
| PUBMED: | 23292310 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 October 2013" - "Source: Scopus" |
