Genetic dissection of ventral folding morphogenesis in mouse: Embryonic visceral endoderm-supplied BMP2 positions head and heart Journal Article

   

Authors:	Gavrilov, S.; Lacy, E.
Article Title:	Genetic dissection of ventral folding morphogenesis in mouse: Embryonic visceral endoderm-supplied BMP2 positions head and heart
Abstract:	Ventral folding morphogenesis (VFM), a vital morphogenetic process in amniotes, mediates gut endoderm internalization, linear heart tube formation, ventral body wall closure and encasement of the fetus in extraembryonic membranes. Aberrant VFM underlies a number of birth defects such as gastroschisis and ectopia cordis in human and misplacement of head and heart in mouse. Recent cell lineage-specific mouse mutant analyses identified the Bone Morphogenetic Protein (BMP) pathway and Anterior Visceral Endoderm (AVE) as key regulators of anterior VFM. Loss of BMP2 expression solely from embryonic visceral endoderm (EmVE) and the AVE blocks formation of foregut invagination, and simultaneously, aberrantly positions the heart anterior/dorsal to the head, suggesting a mechanistic link between foregut and head/heart morphogenesis. © 2013 Elsevier Ltd.
Journal Title:	Current Opinion in Genetics and Development
Volume:	23
Issue:	4
ISSN:	0959-437X
Publisher:	Elsevier Inc.
Date Published:	2013-08-01
Start Page:	461
End Page:	469
Language:	English
DOI:	10.1016/j.gde.2013.04.001
PROVIDER:	scopus
PMCID:	PMC3759531
PUBMED:	23706163
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84883450963&partnerID=40&md5=b554650a894001580feef66784cd98cf
Notes:	--- - "Export Date: 1 October 2013" - "CODEN: COGDE" - "Source: Scopus"

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