Acute myelogenous leukemia stem cells: From Bench to Bedside Journal Article
| Authors: | Felipe Rico, J.; Hassane, D. C.; Guzman, M. L. |
| Article Title: | Acute myelogenous leukemia stem cells: From Bench to Bedside |
| Abstract: | Despite reaching remission with traditional chemotherapy, most adult patients with acute myeloid leukemia (AML) will relapse and die of their disease. Numerous studies have identified a rare subset of leukemia cells that evade traditional chemotherapy and are capable of self-renewal and initiating leukemia. These cells are thought to be responsible for relapse and are termed leukemia stem cells (LSCs). This article will review the current LSC translational research and focus on new approaches to detect LSC burden and its prognostic implications, as well as the identification and development of therapeutic agents active against LSCs. © 2012 Elsevier Ireland Ltd. |
| Keywords: | signal transduction; leukemia; unclassified drug; acute granulocytic leukemia; drug efficacy; nonhuman; drug targeting; antineoplastic agent; cell proliferation; cd34 antigen; apoptosis; bortezomib; neoplasm recurrence, local; gene expression profiling; cell renewal; monoclonal antibody; temsirolimus; membrane antigen; myelodysplastic syndrome; drug mechanism; neoplastic stem cells; leukemia, myeloid; cancer stem cell; cell subpopulation; genomics; short survey; target cell; cyclopamine; obatoclax; oblimersen; cd38 antigen; acute disease; wortmannin; leukemia stem cell; gemtuzumab ozogamicin; parthenolide; acute myelogenous leukemia; therapies; aml; tumor microenvironment; molecularly targeted therapy; chemoresistance; navitoclax; 4 hydroxynonenal; cancer prognosis; celastrol; translational medical research; lsc; csl 360; echinomycin; monoclonal antibody 7g3; monoclonal antibody h90; sl 401 |
| Journal Title: | Cancer Letters |
| Volume: | 338 |
| Issue: | 1 |
| ISSN: | 0304-3835 |
| Publisher: | Elsevier Ireland Ltd. |
| Date Published: | 2013-09-10 |
| Start Page: | 4 |
| End Page: | 9 |
| Language: | English |
| DOI: | 10.1016/j.canlet.2012.05.034 |
| PROVIDER: | scopus |
| PUBMED: | 22713929 |
| PMCID: | PMC4374350 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 October 2013" - "CODEN: CALED" - "Source: Scopus" |
