Tissue damage detection by osmotic surveillance Journal Article

   


Authors: Enyedi, B.; Kala, S.; Nikolich Zugich, T.; Niethammer, P.
Article Title: Tissue damage detection by osmotic surveillance
Abstract: How tissue damage is detected to induce inflammatory responses is unclear. Most studies have focused on damage signals released by cell breakage and necrosis. Whether tissues use other cues in addition to cell lysis to detect that they are damaged is unknown. We find that osmolarity differences between interstitial fluid and the external environment mediate rapid leukocyte recruitment to sites of tissue damage in zebrafish by activating cytosolic phospholipase a2 (cPLA2) at injury sites. cPLA2 initiates the production of non-canonical arachidonate metabolites that mediate leukocyte chemotaxis through a 5-oxo-ETE receptor (OXE-R). Thus, tissues can detect damage through direct surveillance of barrier integrity, with cell swelling probably functioning as a pro-inflammatory intermediate in the process. © 2013 Macmillan Publishers Limited. All rights reserved.
Journal Title: Nature Cell Biology
Volume: 15
Issue: 9
ISSN: 1465-7392
Publisher: Nature Publishing Group  
Date Published: 2013-09-01
Start Page: 1123
End Page: 1130
Language: English
DOI: 10.1038/ncb2818
PROVIDER: scopus
PUBMED: 23934216
PMCID: PMC3826879
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84883742982&partnerID=40&md5=8d37d4549c28cc204c5ab86c3be58d45
Notes: --- - "Export Date: 1 October 2013" - "CODEN: NCBIF" - "Source: Scopus"
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MSK Authors
  1. Philipp M Niethammer
    34 Niethammer
  2. Balazs Gabor Enyedi
    10 Enyedi
  3. Snigdha Kala
    1 Kala
  4. Tijana Nikolich-Zugich
    1 Nikolich-Zugich
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