C-MET and HGF mRNA expression in hepatocellular carcinoma: Correlation with clinicopathological features and survival Journal Article


Authors: Ang, C. S. P.; Sun, M. Y.; Huitzil-Melendez, D. F.; Chou, J. F. L.; Capanu, M.; Jarnagin, W.; Fong, Y.; DeMatteo, R. P.; D'Angelica, M.; Allen, P.; Chen, C. T.; O'Reilly, E. M.; Weiser, M. R.; Abou-Alfa, G. K.
Article Title: C-MET and HGF mRNA expression in hepatocellular carcinoma: Correlation with clinicopathological features and survival
Abstract: Background/Aim: Data on the clinicopathological features and prognostic impact of c-N-Methyl-N'-nitro-Nnitroso- guanidine HOS Transforming gene (c-MET) and hepatocyte growth factor (HGF) in hepatocellular carcinoma (HCC) are inconsistent. We assessed c-MET and HGF expression in 49 patients with early-stage HCC and correlated the results with disease characteristics and survival. Materials and Methods: Expression of c-MET and HGF mRNA in tumor (T) and non-tumor (NT) tissues was assessed. Results were correlated with patient characteristics and overall and recurrence-free survival. Results: Median relative tumor c-MET and HGF expressions were 3.23 (T/NT ratio 6.46) and 9.07 (T/NT ratio 0.77), respectively. c-MET and HGF were overexpressed in early-stage disease with favorable characteristics although there was no association with survival. Conclusion: Contrary to other studies, in our series increased tumor c-MET and HGF expressions were associated with favorable disease attributes but not with survival. The prognostic and therapeutic applications of this knowledge to HCC are under active investigation.
Keywords: adult; cancer survival; clinical article; protein expression; aged; overall survival; disease course; hepatocellular carcinoma; liver cell carcinoma; cancer staging; cancer grading; patient assessment; abdominal pain; aspartate aminotransferase blood level; scatter factor; aspartate aminotransferase; lung metastasis; albumin; messenger rna; cancer size; perineural invasion; scatter factor receptor; recurrence free survival; albumin blood level; c-met; cancer prognosis; lymph vessel metastasis; hepatocyte growth factor (hgf)
Journal Title: Anticancer Research
Volume: 33
Issue: 8
ISSN: 0250-7005
Publisher: International Institute of Anticancer Research  
Date Published: 2013-08-01
Start Page: 3241
End Page: 3246
Language: English
PROVIDER: scopus
PUBMED: 23898085
DOI/URL:
Notes: --- - "Export Date: 1 October 2013" - "CODEN: ANTRD" - "Source: Scopus"