Risk of rash associated with lenalidomide in cancer patients: A systematic review of the literature and meta-analysis Journal Article
| Authors: | Nardone, B.; Wu, S.; Garden, B. C.; West, D. P.; Reich, L. M.; Lacouture, M. E. |
| Article Title: | Risk of rash associated with lenalidomide in cancer patients: A systematic review of the literature and meta-analysis |
| Abstract: | Background: Lenalidomide is indicated for treatment of multiple myeloma in combination with dexamethasone and as a single agent in myelodysplastic syndromes. The incidence and risk of rash has been inconsistently reported. Materials and Methods: We conducted a systematic review and metaanalysis of the literature to determine the incidence and risk of developing rash. Relevant studies were identified from PubMed and abstracts presented at American Society of Clinical Oncology annual meetings. Incidence, relative risk, and 95% confidence intervals were calculated. Results: Ten trials were available for analysis, and the overall incidence of all-grade and high-grade rash was 27.2% and 3.6%, respectively. Lenalidomide was associated with increased risk of all-grade rash (P <.001). Conclusion: Further studies for prevention and treatment of this toxicity are needed to minimize effect on quality of life and dose intensity. © 2013 Elsevier Inc. All rights reserved. |
| Keywords: | myelofibrosis; lenalidomide; myeloid metaplasia; placebo; drug dose comparison; drug safety; monotherapy; cancer patient; drug eruption; multiple myeloma; incidence; dexamethasone; high risk patient; risk assessment; rash; disease severity; myelodysplastic syndrome; nonhodgkin lymphoma; systematic review; chronic lymphatic leukemia; meta analysis; myeloma; randomized controlled trial (topic); phase 2 clinical trial (topic); phase 3 clinical trial (topic); myelodyplastic syndrome; skin toxicities |
| Journal Title: | Clinical Lymphoma, Myeloma and Leukemia |
| Volume: | 13 |
| Issue: | 4 |
| ISSN: | 2152-2650 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2013-08-01 |
| Start Page: | 424 |
| End Page: | 429 |
| Language: | English |
| DOI: | 10.1016/j.clml.2013.03.006 |
| PROVIDER: | scopus |
| PUBMED: | 23769670 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 September 2013" - "Source: Scopus" |
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