Distinguishing benign thymic lesions from early-stage thymic malignancies on computed tomography Journal Article

Authors: McErlean, A.; Huang, J.; Zabor, E. C.; Moskowitz, C. S.; Ginsberg, M. S.
Article Title: Distinguishing benign thymic lesions from early-stage thymic malignancies on computed tomography
Abstract: INTRODUCTION:: The increasing use of computed tomography (CT) has led to frequent identification of asymptomatic lesions in the anterior mediastinum. The purpose of this study is to identify CT features that distinguish benign thymic lesions from early-stage malignant thymic neoplasms. METHODS:: We retrospectively reviewed preoperative CT imaging for 66 patients, who had undergone thymectomy for benign thymic lesions or early-stage malignant thymic neoplasms. All variables with a p value of less than 0.2 on univariate logistic regression analysis were evaluated by multivariate analysis. Stepwise selection was performed, and variables with a p value less than 0.05 were retained in the final model. RESULTS:: Thirty-eight malignant (58%) and 28 benign thymic lesions (42%) were included. Patients with benign thymic tumors were significantly younger (median age, 49.5 years) than patients with malignant tumors (60.0 years; p = 0.007). Malignant tumors were larger in short-axis dimension (p = 0.028) and more frequently in a nonmidline location in the anterior mediastinum (p = 0.029). Intralesional fat was seen exclusively in benign masses (p = 0.002). Seven benign tumors (25%) and one malignant tumor (2.6%) had a triangular thymic shape (p = 0.023). In multivariate analysis, lower age, smaller short-axis dimension, and lack of infiltration of the mediastinal fat were significant independent predictors of benign pathologic results. CONCLUSION:: Intralesional fat, midline location, and triangular thymic shape are more frequently found in benign thymic lesions. Lack of infiltration of the mediastinal fat, younger patient age, and smaller size are independent predictors of benign thymic lesions. These features may help characterize thymic masses as benign and avert potentially unnecessary invasive diagnostic procedures. © 2013 by the International Association for the Study of Lung Cancer.
Keywords: adult; aged; cancer surgery; major clinical study; clinical feature; computer assisted tomography; surgical approach; retrospective study; cancer therapy; age; coughing; dyspnea; thymus; malignant neoplastic disease; carcinoid; benign tumor; myasthenia gravis; thymoma; mediastinum; computed tomography; fat; mediastinal tumor; mediastinum mass; thymus lymphoma
Journal Title: Journal of Thoracic Oncology
Volume: 8
Issue: 7
ISSN: 1556-0864
Publisher: Elsevier Inc.  
Date Published: 2013-07-01
Start Page: 967
End Page: 973
Language: English
DOI: 10.1097/JTO.0b013e3182904bc2
PROVIDER: scopus
PUBMED: 23608816
PMCID: PMC3978781
Notes: --- - "Export Date: 4 September 2013" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Michelle S Ginsberg
    158 Ginsberg
  2. Chaya S. Moskowitz
    173 Moskowitz
  3. James Huang
    119 Huang
  4. Emily Craig Zabor
    131 Zabor