Strategies for relapsed peripheral T-cell lymphoma: the tail that wags the curve Journal Article


Authors: Lunning, M. A.; Moskowitz, A. J.; Horwitz, S.
Article Title: Strategies for relapsed peripheral T-cell lymphoma: the tail that wags the curve
Abstract: A 69-year-old woman was referred for further evaluation and management of relapsed angioimmunoblastic T-cell lymphoma. At diagnosis, she received six cycles of dose-adjusted EPOCH (etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin) and achieved a complete response (CR). Her first surveillance computed tomography scan 3 months later demonstrated enlarging cervical lymphadenopathy. A lymph node excision confirmed relapsed angioimmunoblastic T-cell lymphoma with atypical lymphocytes expressing CD3, CD4, CD10, PD-1, and EBER, with loss of CD5 (Fig 1). A clonal T-cell receptor beta and gamma rearrangement by polymerase chain reaction was identical to that in her initial diagnostic biopsy. At our initial consultation, options for standard as well as investigational therapies were discussed, and HLA typing was initiated. The patient was enrolled onto an investigational phase II study; however, she developed progressive disease after two cycles. She was then treated with romidepsin 14 mg/m(2) administered intravenously for 3 consecutive weeks with 1 week off. After two cycles, she achieved a partial response, and after four additional cycles, she maintained her response without further improvement. We discussed additional treatment options.
Keywords: aged; transplantation, homologous; prednisone; case report; doxorubicin; patient selection; methodology; antineoplastic agent; etoposide; antineoplastic combined chemotherapy protocols; recurrence; cyclophosphamide; vincristine; stem cell transplantation; pathology; peripheral t cell lymphoma; immunology; severity of illness index; computer assisted emission tomography; graft versus host reaction; scintiscanning; recurrent disease; antibiotics, antineoplastic; graft vs host disease; antineoplastic antibiotic; romidepsin; depsipeptides; allotransplantation; induction chemotherapy; depsipeptide; lymphoma, t-cell, peripheral; positron-emission tomography and computed tomography
Journal Title: Journal of Clinical Oncology
Volume: 31
Issue: 16
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 2013-06-01
Start Page: 1922
End Page: 1927
Language: English
DOI: 10.1200/jco.2012.48.3883
PUBMED: 23630204
PROVIDER: scopus
PMCID: PMC3862961
DOI/URL:
Notes: --- - "Export Date: 4 September 2013" - "Source: Scopus"
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MSK Authors
  1. Matthew Alexander Lunning
    26 Lunning
  2. Steven M Horwitz
    350 Horwitz
  3. Alison Moskowitz
    140 Moskowitz