Hybrid imaging of peripheral skeletal disease by SPECT/high-resolution flat-panel CT Journal Article
| Authors: | Lohrmann, C.; Hauschild, O.; Meyer, P. T.; Mix, M.; Strohm, P. C.; Weber, W. A.; Rischke, H. C. |
| Article Title: | Hybrid imaging of peripheral skeletal disease by SPECT/high-resolution flat-panel CT |
| Abstract: | The aim of this study was to determine the impact of high-resolution cone-beam CT with flat-panel detectors on the interpretation of bone SPECT in diseases of the peripheral skeleton. Methods: Forty-one consecutive patients with peripheral skeletal disease were examined with a SPECT/high-resolution CT system providing isotropic voxels of 0.33 × 0.33 × 0.33 mm. High-resolution images were retrospectively analyzed by 2 readers and compared with lowresolution images obtained by filtering the high-resolution images to a lower resolution. Results: SPECT/high-resolution CT demonstrated higher diagnostic confidence scores (1.98 ± 0.27 vs. 1.3 ± 0.45, P < 0.01) and better interobserver agreement (k = 0.5 vs. 0.2) than SPECT/low-resolution CT. The diagnosis made by SPECT/ high-resolution CT was in agreement with the final clinical diagnosis in 95% (reader 1) and 90% (reader 2) of the cases, as compared with 59% (reader 1) and 60% (reader 2) of the cases for SPECT/lowresolution CT (P < 0.01). Conclusion: High-resolution flat-panel CT has the potential to significantly improve SPECT/CT imaging in diseases of the peripheral skeleton. COPYRIGHT © 2013 by the Society of Nuclear Medicine and Molecular Imaging, Inc. |
| Keywords: | adolescent; adult; clinical article; controlled study; aged; middle aged; retrospective studies; young adult; image analysis; image interpretation, computer-assisted; observer variation; diagnostic value; clinical evaluation; scoring system; single photon emission computer tomography; optical resolution; bone disease; cone beam computed tomography; bone radiography; bone diseases; voxel based morphometry; high resolution computer tomography; spect/ct; positron-emission tomography and computed tomography; flat-panel ct; hybrid imaging; skeletal disease; butedronate technetium tc 99m; peripheral skeletal disease |
| Journal Title: | Journal of Nuclear Medicine |
| Volume: | 54 |
| Issue: | 8 |
| ISSN: | 0161-5505 |
| Publisher: | Society of Nuclear Medicine |
| Date Published: | 2013-08-01 |
| Start Page: | 1323 |
| End Page: | 1326 |
| Language: | English |
| DOI: | 10.2967/jnumed.112.116343 |
| PROVIDER: | scopus |
| PUBMED: | 23704320 |
| DOI/URL: | |
| Notes: | "Export Date: 4 September 2013" - "CODEN: JNMEA" - "Source: Scopus" |
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