A clear picture of renal cell carcinoma Journal Article


Authors: Hakimi, A. A.; Pham, C. G.; Hsieh, J. J.
Article Title: A clear picture of renal cell carcinoma
Abstract: Two recent studies describe the largest molecular profiling analyses to date of clear-cell renal cell carcinoma (ccRCC) and report remarkably similar findings. The recurrent pathway alterations identified in these studies open new avenues for therapeutic advances in this chemotherapy- and radiation-resistant disease. © 2013 Nature America, Inc. All rights reserved.
Keywords: cancer chemotherapy; single nucleotide polymorphism; missense mutation; disease course; protein conformation; gene expression profiling; genetic association; genetic variability; mutational analysis; phosphatidylinositol 3 kinase; kidney carcinoma; algorithm; gene identification; mammalian target of rapamycin; radiosensitivity; heterozygosity loss; chromosome 8; chromosome analysis; metabolic disorder; transcriptome; glutamine; chromosome 3p; citric acid cycle; histone modification; hydroxymethylglutaryl coenzyme a reductase kinase; haploinsufficiency; elongin c
Journal Title: Nature Genetics
Volume: 45
Issue: 8
ISSN: 1061-4036
Publisher: Nature Publishing Group  
Date Published: 2013-08-01
Start Page: 849
End Page: 850
Language: English
DOI: 10.1038/ng.2708
PROVIDER: scopus
PUBMED: 23892664
DOI/URL:
Notes: --- - "Export Date: 4 September 2013" - "CODEN: NGENE" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. James J Hsieh
    116 Hsieh
  2. Can Gia Pham
    8 Pham
  3. Abraham Ari Hakimi
    140 Hakimi