Long-term outcomes comparing surgery to embolization-ablation for treatment of solitary HCC <7 cm Journal Article


Authors: Elnekave, E.; Erinjeri, J. P.; Brown, K. T.; Thornton, R. H.; Petre, E. N.; Maybody, M.; Maluccio, M. A.; Hsu, M.; Sofocleous, C. T.; Getrajdman, G. I.; Brody, L. A.; Solomon, S. B.; Alago, W.; Fong, Y.; Jarnagin, W. R.; Covey, A. M.
Article Title: Long-term outcomes comparing surgery to embolization-ablation for treatment of solitary HCC <7 cm
Abstract: Background: Resection has been the standard of care for patients with solitary hepatocellular carcinoma (HCC). Transarterial embolization and percutaneous ablation are alternative therapies often reserved for suboptimal surgical candidates. Here we compare long-term outcomes of patients with solitary HCC treated with resection versus combined embo-ablation. Methods: We previously reported a retrospective comparison of resection and embo-ablation in 73 patients with solitary HCC <7 cm after a median follow-up of 23 months. This study represents long-term updated follow-up over a median of 134 months. Results: There was no difference in survival among Okuda I patients who underwent resection versus embo-ablation (66 vs 58 months, p =.39). There was no difference between the groups in the rate of distant intrahepatic (p =.35) or metastatic progression (p =.48). Surgical patients experienced more complications (p =.004), longer hospitalizations (p <.001), and were more likely to require hospital readmission within 30 days of discharge (p =.03). Conclusion: Over a median follow up of more than 10 years, we found no significant difference in overall survival of Okuda 1 patients with solitary HCC <7 cm who underwent surgical resection versus embo-ablation. Our data suggest that there may be a greater role for primary embo-ablation in the treatment of potentially resectable solitary HCC. © 2013 Society of Surgical Oncology.
Journal Title: Annals of Surgical Oncology
Volume: 20
Issue: 9
ISSN: 1068-9265
Publisher: Springer  
Date Published: 2013-09-01
Start Page: 2881
End Page: 2886
Language: English
DOI: 10.1245/s10434-013-2961-2
PROVIDER: scopus
PUBMED: 23563960
PMCID: PMC6661155
DOI/URL:
Notes: --- - "Export Date: 4 September 2013" - "CODEN: ASONF" - "Source: Scopus"
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MSK Authors
  1. William Alago
    25 Alago
  2. Meier Hsu
    169 Hsu
  3. Anne Covey
    166 Covey
  4. Majid Maybody
    98 Maybody
  5. William R Jarnagin
    905 Jarnagin
  6. Yuman Fong
    775 Fong
  7. Lynn Brody
    120 Brody
  8. Karen T Brown
    178 Brown
  9. Stephen Solomon
    424 Solomon
  10. Joseph Patrick Erinjeri
    203 Erinjeri
  11. Elena Nadia Petre
    108 Petre