Merlin's tumor suppression linked to inhibition of the E3 ubiquitin ligase CRL4DCAF1 Journal Article
| Authors: | Li, W.; Giancotti, F. G. |
| Article Title: | Merlin's tumor suppression linked to inhibition of the E3 ubiquitin ligase CRL4DCAF1 |
| Abstract: | The mechanism by which the FERM domain protein Merlin, encoded by the tumor suppressor NF2, restrains cell proliferation is poorly understood. Prior studies have suggested that Merlin exerts its antimitogenic effect by interacting with multiple signaling proteins located at or near the plasma membrane. We have recently observed that Merlin translocates into the nucleus and binds to and inhibits the E3 ubiquitin ligase CRL4DCAF1. Genetic evidence indicates that inactivation of Merlin induces oncogenic gene expression, hyperproliferation, and tumorigenicity by unleashing the activity of CRL4DCAF1. In addition to providing a potential explanation for the diverse effects that loss of Merlin exerts in multiple cell types, these findings suggest that compounds inhibiting CRL4DCAF1 may display therapeutic efficacy in Neurofibromatosis type 2 and other cancers driven by Merlin inactivation. © 2010 Landes Bioscience. |
| Keywords: | signal transduction; unclassified drug; review; nonhuman; cell proliferation; neurofibromatosis; enzyme inhibition; gene expression; enzyme inhibitor; carcinogenesis; cancer inhibition; carcinogenicity; cell membrane; cell nucleus; ubiquitin protein ligase e3; merlin; nf2; ferm domain protein; crl4; dcaf1; e3 ubiquitin ligase; mln 4924; protein crl4 dcaf1 |
| Journal Title: | Cell Cycle |
| Volume: | 9 |
| Issue: | 22 |
| ISSN: | 1538-4101 |
| Publisher: | Taylor & Francis Inc. |
| Date Published: | 2010-11-15 |
| Start Page: | 4433 |
| End Page: | 4436 |
| Language: | English |
| DOI: | 10.4161/cc.9.22.13838 |
| PROVIDER: | scopus |
| PMCID: | PMC3048042 |
| PUBMED: | 21084862 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "Source: Scopus" |
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