Case report: Delirium due to a diltiazem-fentanyl CYP3A4 drug interaction Journal Article
| Authors: | Levin, T. T.; Hussien-Bakr, M.; Nikolova, T. |
| Article Title: | Case report: Delirium due to a diltiazem-fentanyl CYP3A4 drug interaction |
| Abstract: | Introduction: Fentanyl and diltiazem are frequently used medications. Diltiazem inhibits cytochrome P450 3A4 isoenzymes. This can suppress fentanyl metabolism. Method: We present a case of delirium after coadministration of fentanyl and diltiazem. Discussion: Cautious use is warranted while concomitantly administering fentanyl and diltiazem as this can potentiate fentanyl toxicity. Other 3A4 inhibitors include ketoconazole, erythromycin, nefazodone, ritonavir, delavirdine, aprepitant and imatinib. Psychosomatic medicine psychiatrists, pain and palliative care physicians and cardiologists in particular should be aware of this interaction. © 2010 Elsevier Inc. |
| Keywords: | aged; human cell; anamnesis; case report; drug dose reduction; drug potentiation; drug withdrawal; side effect; low drug dose; haloperidol; lorazepam; delirium; bedtime dosage; backache; confusion; thorax pain; laboratory test; colitis; clostridium difficile infection; chronic pain; respiration depression; somnolence; vancomycin; drug dose increase; hydromorphone; hallucination; disease exacerbation; supraventricular tachycardia; fentanyl; piperacillin plus tazobactam; agitation; oxycodone; aggression; diltiazem; cytochrome p450 3a4; docusate sodium; ranitidine; lansoprazole; drug interaction cyp3a4; tamsulosin; persecutory delusion |
| Journal Title: | General Hospital Psychiatry |
| Volume: | 32 |
| Issue: | 6 |
| ISSN: | 0163-8343 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2010-11-01 |
| Start Page: | 648.e9 |
| End Page: | 648.e10 |
| Language: | English |
| DOI: | 10.1016/j.genhosppsych.2010.08.003 |
| PROVIDER: | scopus |
| PUBMED: | 21112467 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: GHPSD" - "Source: Scopus" |
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