The role of neoadjuvant therapy in sphincter-saving surgery for mid and distal rectal cancer Journal Article
| Authors: | Leibold, T.; Guillem, Jose G. |
| Article Title: | The role of neoadjuvant therapy in sphincter-saving surgery for mid and distal rectal cancer |
| Abstract: | Current treatment of mid and lower rectal cancer includes neoadjuvant therapy, such as radiotherapy or radiochemotherapy. Randomized trials have demonstrated that neoadjuvant therapy improves local control. However, with the exception of one study, it does not improve overall and cancer-specific survival. In addition, the role of neoadjuvant therapy in enhancing the surgeon's ability to perform sphincter-saving surgery is still controversial. We provide an overview of reported randomized trials using neoadjuvant therapy in patients with rectal cancer. We have examined the most significant factors influencing sphincter preservation and the manner in which these factors are affected by neoadjuvant treatment. Copyright © 2010 Informa Healthcare USA, Inc. |
| Keywords: | cancer survival; surgical technique; survival rate; overall survival; clinical trial; review; cancer recurrence; cisplatin; fluorouracil; capecitabine; cancer adjuvant therapy; preoperative care; radiation dose; neoadjuvant therapy; nuclear magnetic resonance imaging; positron emission tomography; computer assisted tomography; controlled clinical trial; randomized controlled trial; randomized controlled trials as topic; continuous infusion; survival time; intraoperative period; folinic acid; echography; drug response; oxaliplatin; rectal neoplasms; rectum cancer; rectum surgery; rectal cancer; anal canal; neoadjuvant treatment; short course therapy; sphincter preservation; raltitrexed; sphincter saving surgery |
| Journal Title: | Cancer Investigation |
| Volume: | 28 |
| Issue: | 3 |
| ISSN: | 0735-7907 |
| Publisher: | Informa Healthcare |
| Date Published: | 2010-03-01 |
| Start Page: | 259 |
| End Page: | 267 |
| Language: | English |
| DOI: | 10.3109/07357900802112719 |
| PUBMED: | 19857039 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: CINVD" - "Source: Scopus" |
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