Cascade resulting in the reductive ethynylation of aldehydes: Dissection of its components Journal Article
| Authors: | Lee, D.; Danishefsky, S. J. |
| Article Title: | Cascade resulting in the reductive ethynylation of aldehydes: Dissection of its components |
| Abstract: | A mild and efficient two-carbon homologation of aldehydes exploiting multiple modes of KOt-Bu was developed. This process involves a sequential Peterson allenylation/allene-alkyne isomerization/ protodesilylation in a single-flask operation. The differential roles played by the various elements of the process were demonstrated through dissection experiments. © 2010 American Chemical Society. |
| Keywords: | chemical structure; molecular structure; aldehydes; oxidation-reduction; chemical reaction; carbon; isomerization; ethynylation; multiple modes; peterson; acetylene; aldehyde; alkyne; allene derivative; desilylation; alkadienes; alkynes; propanols |
| Journal Title: | Journal of the American Chemical Society |
| Volume: | 132 |
| Issue: | 12 |
| ISSN: | 0002-7863 |
| Publisher: | American Chemical Society |
| Date Published: | 2010-03-31 |
| Start Page: | 4427 |
| End Page: | 4430 |
| Language: | English |
| DOI: | 10.1021/ja910825g |
| PUBMED: | 20201522 |
| PROVIDER: | scopus |
| PMCID: | PMC2847877 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: JACSA" - "Source: Scopus" |
