Knowledge of hepatitis C virus screening in long-term pediatric cancer survivors: A report from the childhood cancer survivor study Journal Article
| Authors: | Lansdale, M.; Castellino, S.; Marina, N.; Goodman, P.; Hudson, M. M.; Mertens, A. C.; Smith, S. M.; Leisenring, W.; Robison, L. L.; Oeffinger, K. C. |
| Article Title: | Knowledge of hepatitis C virus screening in long-term pediatric cancer survivors: A report from the childhood cancer survivor study |
| Abstract: | BACKGROUND: Pediatric cancer survivors who were treated before routine hepatitis C virus (HCV) screening of blood donors in 1992 have an elevated risk of transfusion-acquired HCV. METHODS: To assess long-term pediatric cancer survivors' knowledge of HCV testing and blood transfusion history, a questionnaire was administered to 9242 participants in the Childhood Cancer Survivor Study who are at risk for transfusion-acquired HCV after cancer therapy from 1970 to 1986. RESULTS: More than 70% of survivors reported either no prior HCV testing (41%) or uncertainty about testing (31%), with only 29% reporting prior testing. One half recalled having a treatment-related blood transfusion; those who recalled a transfusion were more likely to report HCV testing (39%) than those who did not (18%) or were unsure (20%). In multivariate models, survivors who reported no prior HCV testing were more likely to be older (odds ratio [OR] per 5-year increase, 1.1; 95% confidence interval [CI], 1.0-1.1) and to report no care at a cancer center within the past 2 years (OR, 1.2; 95% CI, 1.0-1.4), no cancer treatment summary (OR, 1.3; 95% CI, 1.2-1.5), and no transfusions (OR, 2.6; 95% CI, 2.3-3.0) or uncertainty about transfusions (OR, 2.2; 95% CI, 1.9-2.6), and less likely to be racial/ethnic minorities (OR, 0.9; 95% CI, 0.8-1.0) or survivors of acute myeloid leukemia (OR, 0.7; 95% CI, 0.5-1.0). CONCLUSIONS: Many pediatric cancer survivors at risk for transfusion-acquired HCV are unaware of their transfusion history and prior testing for HCV and would benefit from programs to increase HCV knowledge and screening. © 2010 American Cancer Society. |
| Keywords: | adolescent; adult; middle aged; acute granulocytic leukemia; major clinical study; hepatitis c; nonhuman; cancer patient; neoplasms; cancer screening; acute lymphoblastic leukemia; central nervous system tumor; childhood cancer; hodgkin disease; late effects; survivors; chronic disease; cancer center; nonhodgkin lymphoma; neuroblastoma; screening; blood transfusion; survivorship; soft tissue sarcoma; health knowledge, attitudes, practice; ethnic difference; hepatitis c virus; race difference; nephroblastoma; bone cancer; adverse treatment effects |
| Journal Title: | Cancer |
| Volume: | 116 |
| Issue: | 4 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 2010-02-15 |
| Start Page: | 974 |
| End Page: | 982 |
| Language: | English |
| DOI: | 10.1002/cncr.24810 |
| PUBMED: | 20041485 |
| PROVIDER: | scopus |
| PMCID: | PMC2819650 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: CANCA" - "Source: Scopus" |
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