Stabilization of the μ-opioid receptor by truncated single transmembrane splice variants through a chaperone-like action Journal Article
| Authors: | Xu, J.; Xu, M.; Brown, T.; Rossi, G. C.; Hurd, Y. L.; Inturrisi, C. E.; Pasternak, G. W.; Pan, Y. X. |
| Article Title: | Stabilization of the μ-opioid receptor by truncated single transmembrane splice variants through a chaperone-like action |
| Abstract: | Background: The μ-opioid receptor gene undergoes extensive alternative splicing. Results: The single transmembrane (TM) splice variants function as a chaperone to stabilize 7-TM MOR-1, enhancing morphine analgesia. Conclusion: Single TM variants play an important role in expression and function of 7-TM MOR-1. Significance: The function of truncated variants is significant for understanding the regulation ofμ-opioid receptors or other GPCR families. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc. |
| Journal Title: | Journal of Biological Chemistry |
| Volume: | 288 |
| Issue: | 29 |
| ISSN: | 0021-9258 |
| Publisher: | American Society for Biochemistry and Molecular Biology |
| Date Published: | 2013-07-19 |
| Start Page: | 21211 |
| End Page: | 21227 |
| Language: | English |
| DOI: | 10.1074/jbc.M113.458687 |
| PROVIDER: | scopus |
| PUBMED: | 23760268 |
| PMCID: | PMC3774389 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 August 2013" - "CODEN: JBCHA" - "Source: Scopus" |
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