Senescent cells spread the word: Non-cell autonomous propagation of cellular senescence Journal Article
| Authors: | Tasdemir, N.; Lowe, S. W. |
| Article Title: | Senescent cells spread the word: Non-cell autonomous propagation of cellular senescence |
| Abstract: | Senescence has long been considered a cell autonomous arrest programme restricting the propagation of damaged cells in tissues. Now there is accumulating evidence that senescent cells can communicate with their environment. In a recent report by Gil and colleagues (Acosta et al, 2013), it now seems senescence can be transmitted in a paracrine fashion in several in vitro and in vivo contexts. In addition to broadening our understanding of the biology of senescence, these new findings may have interesting implications for tissue homeostasis and future cancer therapies. © 2013 European Molecular Biology Organization. |
| Keywords: | signal transduction; vasculotropin; human cell; mitosis; phenotype; animals; dna damage; protein p16; transforming growth factor beta; mitogenesis; in vitro study; protein p53; oncogene; interleukin 6; cell cycle arrest; upregulation; microenvironment; senescence; immunosurveillance; protein p21; tissue injury; cell aging; immunocompetent cell; monocyte chemotactic protein 1; interleukin 1; inflammasomes |
| Journal Title: | EMBO Journal |
| Volume: | 32 |
| Issue: | 14 |
| ISSN: | 0261-4189 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2013-07-17 |
| Start Page: | 1975 |
| End Page: | 1976 |
| Language: | English |
| DOI: | 10.1038/emboj.2013.139 |
| PROVIDER: | scopus |
| PMCID: | PMC3715860 |
| PUBMED: | 23778965 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 August 2013" - "CODEN: EMJOD" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work