Progress against follicular lymphoma Journal Article
| Authors: | Schatz, J. H.; Oricchio, E.; Puvvada, S. D.; Wendel, H. G. |
| Article Title: | Progress against follicular lymphoma |
| Abstract: | Purpose of Review: To share the recent progress in research and new therapies against follicular lymphoma and highlight the exciting opportunities to improve the treatment of follicular lymphoma. RECENT FINDINGS: Follicular lymphoma has been somewhat neglected by the research community, but recent genomic studies have identified key genetic lesions in follicular lymphoma. In addition, a new murine model is available to explore the function of these lesions in the development, progression, and treatment of follicular lymphoma. Moreover, new small-molecule inhibitors are now available that target key pathways in follicular lymphoma including B-cell receptor signaling and histone modifiers. SUMMARY: Follicular lymphoma is a very common and still incurable form of lymphoma. However, recent genomic and in-vivo biological studies are beginning to unveil the molecular drivers of follicular lymphoma. This coincides with the development of effective small-molecule inhibitors against key targets. Together these developments suggest that we are at a long overdue watershed moment in the treatment of follicular lymphoma. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins. |
| Keywords: | signal transduction; gene mutation; gene sequence; pathogenesis; review; cancer growth; nonhuman; antineoplastic agents; phenotype; animals; mice; cell cycle; cancer immunotherapy; apoptosis; gene locus; in vivo study; protein bcl xl; protein p53; cancer research; carcinogenesis; protein kinase inhibitors; epigenetics; histone; chromatin immunoprecipitation; genomics; lymphocytic infiltration; disease models, animal; oncogene c myc; genetic screening; obatoclax; follicular lymphoma; proto-oncogene proteins c-bcl-2; lymphoma, follicular; therapy; lymphocyte function associated antigen 3; molecular model; chromosome 6q; protein bax; histone modification; protein bak; navitoclax; cell receptor; b lymphocyte receptor; ephrin receptor a7; histone acetylation; ibrutinib; experimental models |
| Journal Title: | Current Opinion in Hematology |
| Volume: | 20 |
| Issue: | 4 |
| ISSN: | 1065-6251 |
| Publisher: | Lippincott Williams & Wilkins, Ltd. |
| Date Published: | 2013-07-01 |
| Start Page: | 320 |
| End Page: | 326 |
| Language: | English |
| DOI: | 10.1097/MOH.0b013e3283622ed6 |
| PROVIDER: | scopus |
| PUBMED: | 23673338 |
| PMCID: | PMC3881317 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 August 2013" - "CODEN: COHEF" - "Source: Scopus" |
