Positron emission tomography for response assessment in desmoplastic small round cell tumor Journal Article

Authors: Magnan, H.; Abramson, S. J.; Price, A. P.; Grewal, R. K.; Merchant, M. S.; LaQuaglia, M. P.; Meyers, P. A.
Article Title: Positron emission tomography for response assessment in desmoplastic small round cell tumor
Abstract: Background: Desmoplastic small round cell tumors (DSRCT) typically have a large stromal component and often are extensively disseminated in the peritoneal cavity at diagnosis. These factors contribute to difficulty in quantifying response to chemotherapy using RECIST or WHO criteria. This study compares the overall disease response to chemotherapy by fluorodeoxyglucose-positron emission tomography (FDG-PET) and computed tomography (CT) in patients with DSRCT. Methods: We conducted a retrospective chart review of 7 patients with DSRCT who were imaged by FDG-PET and CT at diagnosis and after 3 cycles of chemotherapy. Response to chemotherapy was graded according to EORTC metabolic response guidelines and RECIST. Results: All tumors demonstrated some decrease in SUVmax (51%±21%) and longest diameter (23%±8%) with chemotherapy. The best response achieved by FDG-PET was a partial response in 6 patients and by CT was a partial response in 1 patient. Measured response was concordant between the 2 modalities in 2 patients. Conclusions: In this small series response measurement by FDGPET did not always correlate with response measurement by CT. A greater decrease in metabolic activity as compared with size was seen in all patients. Further studies are needed to define the role of FDG-PET in assessing early response of DSRCT to chemotherapy. Copyright © 2012 by Lippincott Williams & Wilkins.
Keywords: positron emission tomography; desmoplastic small round cell tumor; response assessment
Journal Title: Journal of Pediatric Hematology/Oncology
Volume: 35
Issue: 5
ISSN: 1077-4114
Publisher: Lippincott Williams & Wilkins  
Date Published: 2013-07-01
Start Page: e190
End Page: e193
Language: English
DOI: 10.1097/MPH.0b013e3182707d4c
PROVIDER: scopus
PUBMED: 23073043
Notes: --- - "Export Date: 1 August 2013" - "CODEN: JPHOF" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Anita P Price
    44 Price
  2. Ravinder K Grewal
    70 Grewal
  3. Paul Meyers
    287 Meyers
  4. Heather Magnan
    28 Magnan