α7 helix region of αI domain is crucial for integrin binding to endoplasmic reticulum chaperone gp96 A potential therapeutic target for cancer metastasis Journal Article
| Authors: | Hong, F.; Liu, B.; Chiosis, G.; Gewirth, D. T.; Li, Z. |
| Article Title: | α7 helix region of αI domain is crucial for integrin binding to endoplasmic reticulum chaperone gp96 A potential therapeutic target for cancer metastasis |
| Abstract: | Background: Integrins are chaperoned by gp96, but the binding region to gp96 remains unknown. Results: Deletion of α7 helix from αI domain of integrin abolished the interaction between integrin and gp96. Targeting this region by corresponding peptide blocked cell invasion. Conclusion: We successfully mapped the binding region of integrin to gp96. Significance: This study will facilitate the development of new cancer therapeutics. © 2013 by The American Society. |
| Journal Title: | Journal of Biological Chemistry |
| Volume: | 288 |
| Issue: | 25 |
| ISSN: | 0021-9258 |
| Publisher: | American Society for Biochemistry and Molecular Biology |
| Date Published: | 2013-06-21 |
| Start Page: | 18243 |
| End Page: | 18248 |
| Language: | English |
| DOI: | 10.1074/jbc.M113.468850 |
| PROVIDER: | scopus |
| PMCID: | PMC3689966 |
| PUBMED: | 23671277 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 August 2013" - "CODEN: JBCHA" - "Source: Scopus" |
