The role of cytotoxic and regulatory T cells in relapsed/refractory hodgkin lymphoma Journal Article


Authors: Koreishi, A. F.; Saenz, A. J.; Persky, D. O.; Cui, H.; Moskowitz, A.; Moskowitz, C. H.; Teruya-Feldstein, J.
Article Title: The role of cytotoxic and regulatory T cells in relapsed/refractory hodgkin lymphoma
Abstract: Recent data suggests the presence of cytotoxic (TIA-1 and granzyme B+) and regulatory T-cells (FOXP3+) in classical Hodgkin lymphoma (cHL) tissues has been shown to correlate with poor overall survival in mainly diagnostic biopsies. By tissue microarray analyses, we extend this observation to a cohort of relapsed/refractory cHL tissue biopsies and analyze immunohistochemical expression of FOXP3, TIA-1, and granzyme B in the inflammatory background and the tumor microenvironment. High expression of TIA-1 (>50%) correlated with poor overall survival (P<0.0001), low expression of FOXP3 (<25%) correlated with poor overall survival (P<0.01), and combined high TIA-1 (>50%) and low FOXP3 (<25%) correlated with poor overall survival (P<0.0001). Expression of cytotoxic and regulatory T-cells shows prognostic significance in the relapsed/refractory clinical setting of cHL. Copyright © 2010 by Lippincott Williams & Wilkins.
Keywords: immunohistochemistry; adolescent; adult; controlled study; human tissue; protein expression; middle aged; survival analysis; unclassified drug; major clinical study; overall survival; transcription factor foxp3; forkhead transcription factors; biomarkers; cell function; recurrence; drug resistance, neoplasm; biopsy; hodgkin disease; granzyme b; protein tia 1; regulatory t lymphocyte; t-lymphocytes, regulatory; microarray analysis; membrane protein; cytotoxic t lymphocyte; t-lymphocytes, cytotoxic; predictive value of tests; cancer relapse; immunochemistry; hodgkin lymphoma; granzymes; relapsed/refractory; poly(a)-binding proteins
Journal Title: Applied Immunohistochemistry & Molecular Morphology
Volume: 18
Issue: 3
ISSN: 1541-2016
Publisher: Lippincott Williams & Wilkins  
Date Published: 2010-05-01
Start Page: 206
End Page: 211
Language: English
DOI: 10.1097/PAI.0b013e3181c7138b
PUBMED: 20065852
PROVIDER: scopus
PMCID: PMC3260943
DOI/URL:
Notes: --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: AIMMF" - "Source: Scopus"
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MSK Authors
  1. Craig Moskowitz
    392 Moskowitz
  2. Julie T Feldstein
    292 Feldstein
  3. Alison Moskowitz
    187 Moskowitz