Terminal loop-mediated regulation of miRNA biogenesis: Selectivity and mechanisms Journal Article


Authors: Castilla-Llorente, V.; Nicastro, G.; Ramos, A.
Article Title: Terminal loop-mediated regulation of miRNA biogenesis: Selectivity and mechanisms
Abstract: Regulating the expression of individual miRNAs (microRNAs) is important for cell development and function. The up- or down-regulation of the processing of specific miRNA precursors to the mature active form represents one tool to control miRNA concentration and is mediated by proteins that recognize the terminal loop of the RNA precursors. Terminal loop recognition is achieved by the combined action of several RNAbinding domains. The proteins can then regulate the processing by recruiting RNA enzymes, changing the RNA structure and preventing or enhancing the accessibility and processing activity of the core processing complexes. The present review focuses on how terminal loop-binding proteins recognize their RNA targets and mediate their regulatory function(s), and highlights how terminal loop-mediated regulation relates to the broader regulation of mRNA metabolism. © 2013 Biochemical Society.
Keywords: protein-rna interaction; combinatorial recognition; microrna biogenesis (mirna biogenesis); multifunctional protein; terminal loop
Journal Title: Biochemical Society Transactions
Volume: 41
Issue: 4
ISSN: 0300-5127
Publisher: Portland Press Ltd  
Date Published: 2013-08-01
Start Page: 861
End Page: 865
Language: English
DOI: 10.1042/bst20130058
PROVIDER: scopus
PUBMED: 23863145
PMCID: PMC3782829
DOI/URL:
Notes: --- - "Export Date: 1 August 2013" - "CODEN: BCSTB" - "Source: Scopus"
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