Shaping the future management of hepatocellular carcinoma Journal Article
| Authors: | Abou-Alfa, G.; Colombo, M. |
| Article Title: | Shaping the future management of hepatocellular carcinoma |
| Abstract: | Several advances in recent years have led to improved surveillance, diagnostic, and treatment options for hepatocellular carcinoma (HCC). Despite these advances, care for this malignancy remains suboptimal, in part because of poor adherence to established guidelines. When diagnosed at an early stage, outcomes for HCC are positive; however, use of appropriate screening techniques and surveillance of at risk patients is still not widely employed. Although a multidisciplinary care team is considered an essential part of successful HCC treatment, fewer than half of the patients with HCC in the United States receive multidisciplinary care. The current suboptimal utilization of potentially curative treatments, including those recommended by treatment guidelines, can be linked to the absence of multidisciplinary care. Additionally, the lack of prognostic and predictive biomarkers for HCC remains challenging, particularly as therapeutic approaches in advanced disease evolve to the use of molecularly targeted agents. Much research is currently focused on the identification of biomarkers for HCC, but improvements in adherence to guidelines for surveillance and appropriate use of available therapies is necessary before care for patients with HCC will improve. Copyright © 2013 by Thieme Medical Publishers, Inc. |
| Keywords: | mitogen activated protein kinase; cancer chemotherapy; cancer survival; treatment outcome; cancer surgery; hepatocellular carcinoma; raf protein; cancer growth; cancer risk; chemoembolization; hepatitis b; hepatitis c; liver cell carcinoma; liver transplantation; cancer staging; cancer diagnosis; diagnostic accuracy; melanoma; breast cancer; gene expression; lung non small cell cancer; epidermal growth factor receptor 2; cancer screening; practice guideline; enzyme activation; protein p53; health care utilization; patient care; epigenetics; echography; cancer size; liver cancer; ras protein; cancer epidemiology; beta catenin; b raf kinase; translational research; randomized controlled trial (topic); molecularly targeted therapy; phase 3 clinical trial (topic); multidisciplinary care; liver carcinogenesis; cancer prognosis; aflatoxin; tivantinib; hcc biomarkers; hcc surveillance; chronic liver disease |
| Journal Title: | Seminars in Liver Disease |
| Volume: | 33 |
| Issue: | Suppl. 1 |
| ISSN: | 0272-8087 |
| Publisher: | Thieme Publishing |
| Date Published: | 2013-02-01 |
| Start Page: | S20 |
| End Page: | S23 |
| Language: | English |
| DOI: | 10.1055/s-0033-1333633 |
| PROVIDER: | scopus |
| PUBMED: | 23457036 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 19 July 2013" - "CODEN: SLDIE" - "Source: Scopus" |
