Loss of 53BP1 is a gain for BRCA1 mutant cells Journal Article
| Authors: | Kass, E. M.; Moynahan, M. E.; Jasin, M. |
| Article Title: | Loss of 53BP1 is a gain for BRCA1 mutant cells |
| Abstract: | Mutations in BRCA1 predispose to tumorigenesis presumably from the inability to accurately repair DNA double-strand breaks by homologous recombination. Two new papers shed light on how loss of the DNA damage response protein 53BP1 reverses phenotypes of BRCA1 mutant cells, with potential clinical implications. © 2010 Elsevier Inc. All rights reserved. |
| Keywords: | signal transduction; unclassified drug; gene mutation; gene deletion; cisplatin; nonhuman; drug targeting; phenotype; homologous recombination; dna repair; cancer susceptibility; ovary cancer; breast cancer; nuclear protein; protein depletion; antineoplastic activity; mutational analysis; brca1 protein; carcinogenesis; cancer resistance; cancer genetics; short survey; chromosomal instability; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor; double stranded dna break; platinum derivative; protein 53bp1 |
| Journal Title: | Cancer Cell |
| Volume: | 17 |
| Issue: | 5 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2010-05-18 |
| Start Page: | 423 |
| End Page: | 425 |
| Language: | English |
| DOI: | 10.1016/j.ccr.2010.04.021 |
| PROVIDER: | scopus |
| PUBMED: | 20478525 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 20 April 2011" - "CODEN: CCAEC" - "Source: Scopus" |
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