Fast radioactive seed localization in intraoperative cone beam CT for low-dose-rate prostate brachytherapy Conference Paper
| Authors: | Hu, Y. C.; Xiong, J. P.; Cohen, G.; Zaider, M.; Mageras, G.; Zelefsky, M. |
| Title: | Fast radioactive seed localization in intraoperative cone beam CT for low-dose-rate prostate brachytherapy |
| Conference Title: | Medical Imaging 2013: Image-Guided Procedures, Robotic Interventions, and Modeling |
| Abstract: | A fast knowledge-based radioactive seed localization method for brachytherapy was developed to automatically localize radioactive seeds in an intraoperative volumetric cone beam CT (CBCT) so that corrections, if needed, can be made during prostate implant surgery. A transrectal ultrasound (TRUS) scan is acquired for intraoperative treatment planning. Planned seed positions are transferred to intraoperative CBCT following TRUS-to-CBCT registration using a reference CBCT scan of the TRUS probe as a template, in which the probe and its external fiducial markers are pre-segmented and their positions in TRUS are known. The transferred planned seeds and probe serve as an atlas to reduce the search space in CBCT. Candidate seed voxels are identified based on image intensity. Regions are grown from candidate voxels and overlay regions are merged. Region volume and intensity variance is checked against known seed volume and intensity profile. Regions meeting the above criteria are flagged as detected seeds; otherwise they are flagged as likely seeds and sorted by a score that is based on volume, intensity profile and distance to the closest planned seed. A graphical interface allows users to review and accept or reject likely seeds. Likely seeds with approximately twice the seed volume are automatically split. Five clinical cases are tested. Without any manual correction in seed detection, the method performed the localization in 5 seconds (excluding registration time) for a CBCT scan with 512x512x192 voxels. The average precision rate per case is 99% and the recall rate is 96% for a total of 416 seeds. All false negative seeds are found with 15 in likely seeds and 1 included in a detected seed. With the new method, updating of calculations of dose distribution during the procedure is possible and thus facilitating evaluation and improvement of treatment quality. © 2013 SPIE. |
| Keywords: | radiotherapy; oncology; computerized tomography; medical imaging; radioactivity; urology; probes; robotics; dose calculation; low dose rate brachytherapy; prostate brachytherapy; knowledge based systems; cone-beam ct; transrectal ultrasound; dynamic dose calculation; intraoperative cone beam ct; radioactive seed localization; evaluation and improvement; graphical interface; seed localization |
| Journal Title | Proceedings of SPIE |
| Volume: | 8671 |
| Conference Dates: | 2013 Feb 9 |
| Conference Location: | Lake Buena Vista, FL |
| ISBN: | 0277-786X |
| Publisher: | SPIE |
| Location: | Lake Buena Vista, FL |
| Date Published: | 2013-01-01 |
| Start Page: | 867108 |
| Language: | English |
| PROVIDER: | scopus |
| DOI: | 10.1117/12.2007957 |
| DOI/URL: | |
| Notes: | --- - Proceedings of SPIE - The International Society for Optical Engineering - Proc SPIE Int Soc Opt Eng - "Conference code: 97261" - "Export Date: 1 July 2013" - "CODEN: PSISD" - ":doi 10.1117/12.2007957" - "Sponsors: Aeroflex Incorporated; CREOL - Univ. Central Florida, Coll. Opt. Photonics; DQE Instruments, Inc.; Medtronic, Inc.; PIXELTEQ, Multispectral Sensing and Imaging" - 12 February 2013 through 14 February 2013 - "Source: Scopus" |
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