Relevance of historical therapeutic approaches to the contemporary treatment of pediatric solid tumors Journal Article
| Authors: | Green, D. M.; Kun, L. E.; Matthay, K. K.; Meadows, A. T.; Meyer, W. H.; Meyers, P. A.; Spunt, S. L.; Robison, L. L.; Hudson, M. M. |
| Article Title: | Relevance of historical therapeutic approaches to the contemporary treatment of pediatric solid tumors |
| Abstract: | Children with solid tumors, most of which are malignant, have an excellent prognosis when treated on contemporary regimens. These regimens, which incorporate chemotherapeutic agents and treatment modalities used for many decades, have evolved to improve relapse-free survival and reduce long-term toxicity. This review discusses the evolution of the treatment regimens employed for management of the most common solid tumors, emphasizing the similarities between contemporary and historical regimens. These similarities allow the use of historical patient cohorts to identify the late effects of successful therapy and to evaluate remedial interventions for these adverse effects. © 2013 Wiley Periodicals, Inc. |
| Keywords: | osteosarcoma; cancer survival; survival rate; review; cancer recurrence; cisplatin; doxorubicin; cancer combination chemotherapy; drug safety; multimodality cancer therapy; solid tumor; cancer adjuvant therapy; cancer radiotherapy; radiation dose; temozolomide; topotecan; glioma; carboplatin; dacarbazine; interleukin 2; progression free survival; multiple cycle treatment; etoposide; granulocyte macrophage colony stimulating factor; cyclophosphamide; melphalan; vincristine; retinoblastoma; ifosfamide; lomustine; central nervous system tumor; childhood cancer; late effects; irinotecan; ewing sarcoma; neuroblastoma; medulloblastoma; dactinomycin; immunomodulation; heterozygosity loss; external beam radiotherapy; isotretinoin; cancer control; rhabdomyosarcoma; anthracycline; neuroectoderm tumor; long-term follow-up; amifostine; teniposide; nephroblastoma; epipodophyllotoxin; childhood cancer therapy; peptichemio |
| Journal Title: | Pediatric Blood and Cancer |
| Volume: | 60 |
| Issue: | 7 |
| ISSN: | 1545-5009 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 2013-07-01 |
| Start Page: | 1083 |
| End Page: | 1094 |
| Language: | English |
| DOI: | 10.1002/pbc.24487 |
| PROVIDER: | scopus |
| PUBMED: | 23418018 |
| PMCID: | PMC3810072 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 July 2013" - "CODEN: PBCEA" - "Source: Scopus" |
