Early negative minimal residual disease in bone marrow after immunotherapy is less predictive of late or non-marrow relapse among patients with high-risk stage 4 neuroblastoma Journal Article

  

Authors:	Cheung, I. Y.; Feng, Y.; Cheung, N. K. V.
Article Title:	Early negative minimal residual disease in bone marrow after immunotherapy is less predictive of late or non-marrow relapse among patients with high-risk stage 4 neuroblastoma
Abstract:	Molecular detection of minimal residual disease (MRD) measured by quantitative reverse transcription-polymerase chain reaction using a four-marker panel in the bone marrow (BM) after only two treatment cycles of anti-GD2 immunotherapy was a strong independent outcome predictor among high-risk patients with stage 4 neuroblastoma in first remission. While 32 of 46 MRD-negative patients relapsed within 2 years from immunotherapy, only four had marrow relapse; in three of these four patients, MRD turned positive in the subsequent BM. We conclude that negative MRD in the post-cycle two BM was rarely associated with BM relapse, but it did not exclude recurrences at other sites. Pediatr Blood Cancer 2013; 60: E32-E34. © 2013 Wiley Periodicals, Inc.
Keywords:	cancer survival; controlled study; unclassified drug; major clinical study; cancer staging; cancer immunotherapy; reverse transcription polymerase chain reaction; granulocyte macrophage colony stimulating factor; relapse; high risk patient; monoclonal antibody; immunotherapy; neuroblastoma; minimal residual disease; isotretinoin; bone marrow disease; late relapse; marrow mrd; pfs; monoclonal antibody gd2
Journal Title:	Pediatric Blood and Cancer
Volume:	60
Issue:	7
ISSN:	1545-5009
Publisher:	Wiley Periodicals, Inc
Date Published:	2013-07-01
Start Page:	E32
End Page:	E34
Language:	English
DOI:	10.1002/pbc.24469
PROVIDER:	scopus
PUBMED:	23335404
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84878228598&partnerID=40&md5=75cb9247f9d203a0bba793cab5c5c16b
Notes:	--- - "Export Date: 1 July 2013" - "CODEN: PBCEA" - "Source: Scopus"

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