Effect of long term imatinib on bone in adults with chronic myelogenous leukemia and gastrointestinal stromal tumors Journal Article


Authors: Berman, E.; Girotra, M.; Cheng, C.; Chanel, S.; Maki, R.; Shelat, M.; Strauss, H. W.; Fleisher, M.; Heller, G.; Farooki, A.
Article Title: Effect of long term imatinib on bone in adults with chronic myelogenous leukemia and gastrointestinal stromal tumors
Abstract: Patients with chronic myelogenous leukemia (CML) or gastrointestinal stromal tumors (GIST) who take imatinib have abnormalities of bone metabolism. However, it is unclear what impact these changes have on bone mineral density (BMD). We prospectively analayzed levels of osteocalcin, a marker of bone formation secreted by osteoblasts, and serum N-telopeptide of type I collagen (NTX), a marker of bone resorption, as well as other minerals involved in bone metabolism in 19 patients with either CML or GIST We correlated these results with changes in bone mineral density as measured by serial dual energy X-ray absorptiometry (DEXA) scans over a two year period. Osteocalcin levels were low in 95% of patients and 37% had no measurable amount. Levels of NTX were less consistent. Nine patients (47%) had a decrease in BMD, four patients (2%) had an increase in BMD, and six patients (32%) had no change. There was no correlation between metabolic markers and change in BMD. We suggest that ongoing management of patients who take imatinib should include monitoring of bone health on a long term basis. © 2013 Elsevier Ltd.
Keywords: imatinib; cml; bone mineral density
Journal Title: Leukemia Research
Volume: 37
Issue: 7
ISSN: 0145-2126
Publisher: Elsevier Ltd  
Date Published: 2013-07-01
Start Page: 790
End Page: 794
Language: English
DOI: 10.1016/j.leukres.2013.02.005
PROVIDER: scopus
PUBMED: 23473999
DOI/URL:
Notes: --- - "Export Date: 1 July 2013" - "CODEN: LERED" - "Source: Scopus"
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MSK Authors
  1. Azeez Farooki
    74 Farooki
  2. Monica Girotra
    22 Girotra
  3. Glenn Heller
    390 Heller
  4. Robert Maki
    221 Maki
  5. Harry W Strauss
    162 Strauss
  6. Suzanne M Chanel
    31 Chanel
  7. Martin Fleisher
    310 Fleisher
  8. Ellin Berman
    165 Berman
  9. Catherine Cheng
    4 Cheng
  10. Meenakshi Shelat
    1 Shelat