Factors predicting outcome in malignant minor salivary gland tumors of the oropharynx Journal Article


Authors: Iyer, N. G.; Kim, L.; Nixon, I. J.; Palmer, F.; Kraus, D.; Shaha, A. R.; Shah, J. P.; Patel, S. G.; Ganly, I.
Article Title: Factors predicting outcome in malignant minor salivary gland tumors of the oropharynx
Abstract: Objectives: To report our experience in the care of patients with minor salivary gland cancers occurring only in the oropharynx and to determine factors predictive of outcome. Design: Retrospective analysis. Setting: Memorial Sloan-Kettering Cancer Center. Patients: Sixty-seven patients with malignant minor salivary gland tumors were identified from a preexisting database of patients with cancers of the oropharynx between January 1985 and December 2005. Main Outcome Measures: Overall survival, diseasespecific survival, and recurrence-free survival were calculated by the Kaplan-Meier method. Factors predictive of outcome were identified by univariate and multivariate analyses. Results: The most common histologic types were mucoepidermoid carcinoma in 26 patients (39%), adenoid cystic carcinoma in 16 (24%), adenocarcinoma in 16 (24%), and malignant mixed tumor in 7 (10%). The tumors were located in the base of the tongue in 41 patients (61%), soft palate in 20 (30%), and tonsil in 6 (9%). With a median follow-up time of 86 months (range, 12-249 months), overall outcomes at 5 and 10 years were overall survival, 80% and 53%; disease-specific survival, 87% and 67%; and recurrence-free survival, 69% and 60%, respectively. Tumor recurred in 20 patients (34%); 12 of these patients had locoregional failure and 15 developed distant metastases. Multivariate analyses showed that clinical T stage, anatomic subsite, and margin status were independent predictors for overall survival; T stage and margin status were independent predictors for locoregional recurrence-free survival. Conclusion: Clinical T stage, anatomic subsite, and margin status are independent predictors of outcome of patients with minor salivary gland cancers of the oropharynx. ©2010 American Medical Association. All rights reserved.
Keywords: adult; cancer survival; human tissue; treatment outcome; aged; major clinical study; overall survival; disease free survival; cancer staging; metastasis; histology; oropharynx cancer; salivary gland cancer
Journal Title: Archives of Otolaryngology - Head & Neck Surgery
Volume: 136
Issue: 12
ISSN: 0886-4470
Publisher: American Medical Association  
Date Published: 2010-12-01
Start Page: 1240
End Page: 1247
Language: English
DOI: 10.1001/archoto.2010.213
PROVIDER: scopus
PUBMED: 21173374
DOI/URL:
Notes: --- - "Export Date: 20 April 2011" - "CODEN: AONSE" - "Source: Scopus"
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MSK Authors
  1. Dennis Kraus
    268 Kraus
  2. Ashok R Shaha
    698 Shaha
  3. Snehal G Patel
    412 Patel
  4. Leslie Kim
    4 Kim
  5. Narayanan Gopalakrishna Iyer
    16 Iyer
  6. Iain James Nixon
    60 Nixon
  7. Ian Ganly
    431 Ganly
  8. Jatin P Shah
    722 Shah
  9. Frank Palmer
    82 Palmer